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Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source
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Numerical Methods

2008
This chapter focuses on the method for obtaining the solution of a mathematical problem in the form of numbers. It discusses the general principles underlying some of the more important numerical methods and treats the simplest ones in detail. The discussion emphasizes that nearly all numerical operations are necessarily accompanied by errors, and the ...
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Numerical Methods

Numerical methods are a cornerstone of modern engineering. This lucid textbook strikes a balance between theory and analysis of numerical methods and their practical applications in engineering. Each chapter starts with the formulation and graphical representation of the numerical method.
Jiaoyan Li, James D. Lee
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NUMERICAL MODELS | Methods

2003
Numerical modeling of the atmosphere is challenging because of the enormous range of space and timescales involved, and because many qualitative features, such as balance and conservation, must be accurately captured. We discuss here a number of topics that have proved important historically in the development of numerical models of the atmosphere ...
openaire   +1 more source

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