Results 271 to 280 of about 2,855,492 (322)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Weak wall boundary conditions for compressible flows. [PDF]

Eng Comput
Jaiswal M, Rajanna MR, Islam MR, Hsu MC, Bazilevs Y.   +4 more
europepmc   +1 more source

Development a practical method for calculation of the block volume and block surface in a fractured rock mass. [PDF]

Sci Rep
Shahbazi A, Saeidi A, Rouleau A, Chesnaux R.   +3 more
europepmc   +1 more source

Multiscale Viscoelastic Analysis of Asphalt Concrete. [PDF]

Materials (Basel)
Klimczak M.
europepmc   +1 more source

Mathematical modeling and cost-effective intervention strategies for diabetes management: A data-driven and numerical analysis approach. [PDF]

PLoS One
Nivetha S, Ghosh M.
europepmc   +1 more source

Output stream analysis in a queueing model with working vacation mechanism as a power reduction strategy. [PDF]

PLoS One
Kobielnik M, Kempa WM.
europepmc   +1 more source

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Numerical Methods

2008
This chapter focuses on the method for obtaining the solution of a mathematical problem in the form of numbers. It discusses the general principles underlying some of the more important numerical methods and treats the simplest ones in detail. The discussion emphasizes that nearly all numerical operations are necessarily accompanied by errors, and the ...
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Numerical Methods

Numerical methods are a cornerstone of modern engineering. This lucid textbook strikes a balance between theory and analysis of numerical methods and their practical applications in engineering. Each chapter starts with the formulation and graphical representation of the numerical method.
Jiaoyan Li, James D. Lee
  +4 more sources

NUMERICAL MODELS | Methods

2003
Numerical modeling of the atmosphere is challenging because of the enormous range of space and timescales involved, and because many qualitative features, such as balance and conservation, must be accurately captured. We discuss here a number of topics that have proved important historically in the development of numerical models of the atmosphere ...
openaire   +1 more source