From Payload‐First Toward Dual‐Mechanism Antibody–Drug Conjugates
Advanced Materials, EarlyView.Conjugation converts potent antibodies into underexposed carriers. This perspective defines the antibody exposure deficit and maps a mechanism‐first design space from payload‐first to antibody‐first ADC architectures, integrating DAR, linker chemistry, and Fc engineering to guide rational design of constructs that balance targeted cytotoxicity with ...
Xavier Pivot +3 more
wiley +1 more source
Gas network value chain optimization considering compressor capacity constraints. [PDF]
PLoS OneQiu J, Zhao L, Ning X, Yu D.
europepmc +1 more source
Understanding Operando Water Management in Hydroxide‐Exchange‐Membrane Fuel Cells
Advanced Materials Interfaces, EarlyView.Effective water management is vital for high‐performance hydroxide‐exchange‐membrane fuel cells. Using a custom water‐flux station, this study quantifies how membrane thickness, microporous layers, and operating conditions dictate internal water transport.
Catherine M. Weiss +4 more
wiley +1 more source
Fast Numerical Solvers for Parameter Identification Problems in Mathematical Biology. [PDF]
J Sci ComputBenková K, Pearson JW, Ptashnyk M.
europepmc +1 more source
A Hybrid Computational Framework for PCF‐based SPR Sensor With Machine Learning and xAI
Advanced Materials Interfaces, EarlyView.A photonic crystal fiber‐based surface plasmon resonance (SPR) sensor integrating rectangular air holes along with conventional circular air holes achieves exceptional wavelength sensitivity of 15,000 nm/RIU across a broad refractive index range of 1.31–1.39. Integrated machine learning with explainable AI (xAI) models achieves high prediction accuracy
Mahabur Rahman Fahim +3 more
wiley +1 more source
Artificial Synaptic Device Based on Self‐Aligned c‐In2O3 TFTs With an Ultrathin MgO Interlayer
Advanced Materials Technologies, EarlyView.A coplanar synaptic thin‐film transistor based on crystalline In2O3 is demonstrated using a PECVD SiO2 gate insulator and an ultrathin MgO interlayer. The MgO interlayer suppresses excessive carrier density and may facilitate proton‐related interfacial polarization, resulting in stable counterclockwise hysteresis and synaptic behavior.
Samiran Roy, Jewel Kumer Saha, Jin Jang
wiley +1 more source
AI-assisted reliability-based design framework for tunnel concrete linings in weak rocks. [PDF]
Sci RepKhani J +4 more
europepmc +1 more source
Advanced Robotics Research, EarlyView.A soft robotic simulator is developed to replicate the digital removal of feces (DRF), a sensitive yet essential nursing procedure. Integrating soft actuators, sensors, and a realistic rectal model, the simulator balances functional fidelity with perceptual realism. Engineering evaluations and nurse feedback confirm its potential to enhance training in
Shoko Miyagawa +10 more
wiley +1 more source
Efficient next-generation reservoir computing: An analog in-memory implementation using memristor crossbar arrays. [PDF]
iScienceLin Z +5 more
europepmc +1 more source
From Rigid to Soft Robotic Approaches for Neuroendoscopy
Advanced Robotics Research, EarlyView.Robotic assistance has had minimal impact on deep intraventricular surgeries, where small‐scale, precision, and reduced invasiveness can contribute to improved patient outcomes. Emerging technologies in rigid, soft, and hybrid robotics are reviewed to identify the most promising mechanisms for deep brain navigation in addition to an attempt to identify
Kieran Gilday +3 more
wiley +1 more source