Results 51 to 60 of about 137,700 (252)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Continuous feedback fluid queues [PDF]

, 2003
We investigate a fluid buffer which is modulated by a stochastic background process, while the momentary behavior of the background process depends on the current buffer level in a continuous way. Loosely speaking the feedback is such that the background
Foreest, N.D. van, Mandjes, M.R.H., Scheinhardt, W.R.W.   +2 more
core   +1 more source

The Spherical Tensor Gradient Operator

, 2005
The spherical tensor gradient operator ${\mathcal{Y}}_{\ell}^{m} (\nabla)$, which is obtained by replacing the Cartesian components of $\bm{r}$ by the Cartesian components of $\nabla$ in the regular solid harmonic ${\mathcal{Y}}_{\ell}^{m} (\bm{r})$, is ...
Weniger, Ernst Joachim
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Measuring Residual Stresses with Crack Compliance Methods: An Ill-Posed Inverse Problem with a Closed-Form Kernel

Applied Mechanics
By means of relaxation methods, residual stresses can be obtained by introducing a progressive cut or a hole in a specimen and by measuring and elaborating the strains or displacements that are consequently produced.
Marco Beghini, Tommaso Grossi
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Implementation of the Combined--Nonlinear Condensation Transformation

, 2002
We discuss several applications of the recently proposed combined nonlinear-condensation transformation (CNCT) for the evaluation of slowly convergent, nonalternating series.
Abe, Abe, Aksenov, Bailey, Bailey, Bailey, Bailey, Bailey, Baratella, Bateman, Blaisdell, Boersma, Bromwich, Champernowne, Daniel, Darwin, Dempsey, Dempsey, Denisov, Doray, Drake, Fisher, Forrey, Gamow, Gautschi, Gerhard Soff, Gnedenko, Good, Haywood, Herdan, Homeier, Jens Becher, Jentschura, Jentschura, Jentschura, Jentschura, Jentschura, Jentschura, Jentschura, Johnson, Karlin, Knopp, Konopka, Kulasekera, Levin, Macdonald, Mandelbrot, Mantegna, Martindale, Michael A. Savageau, Mohr, Olver, Pachucki, Peter J. Mohr, Sergej V. Aksenov, Sidi, Simon, Truesdell, Tsallis, Tsallis, Ulrich D. Jentschura, van Wijngaarden, Weniger, Weniger, Williams, Wolfram, Yule, Zipf, Zörnig   +68 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Boundary integral equation analysis for suspension of spheres in Stokes flow

, 2018
We show that the standard boundary integral operators, defined on the unit sphere, for the Stokes equations diagonalize on a specific set of vector spherical harmonics and provide formulas for their spectra.
Corona, Eduardo, Veerapaneni, Shravan
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source