Results 81 to 90 of about 3,339 (307)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

A New Efficient Method for the Numerical Solution of Linear Time-Dependent Partial Differential Equations

open access: yesAxioms, 2018
This paper presents a new efficient method for the numerical solution of a linear time-dependent partial differential equation. The proposed technique includes the collocation method with Legendre wavelets for spatial discretization and the three-step ...
Mina Torabi, Mohammad-Mehdi Hosseini
doaj   +1 more source

Using wavelets for time series forecasting: Does it pay off? [PDF]

open access: yes
By means of wavelet transform a time series can be decomposed into a time dependent sum of frequency components. As a result we are able to capture seasonalities with time-varying period and intensity, which nourishes the belief that incorporating the ...
Schlüter, Stephan, Deuschle, Carola
core  

An Efficient Numerical Method Based on Bell Wavelets for Solving the Fractional Integro-Differential Equations with Weakly Singular Kernels

open access: yes
A novel numerical scheme based on the Bell wavelets is proposed to obtain numerical solutions of the fractional integro-differential equations with weakly singular kernels.
Yanxin Wang, Xiaofang Zhou
core   +1 more source

Haar wavelets method for solving Pocklington's integral equation [PDF]

open access: yes, 1991
summary:A simple and effective method based on Haar wavelets is proposed for the solution of Pocklington’s integral equation. The properties of Haar wavelets are first given.
G. Beylkin   +6 more
core   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian   +8 more
wiley   +1 more source

Numerical integration based on linear Legendre multi wavelets

open access: yes, 2018
In the present work, a new direct computational method for solving definite integrals based on linear Legendre multi wavelets is introduced. This approach is an improvement of previous methods which are based on Haar wavelets functions.
Asbullah, Muhammad Asyraf   +3 more
core   +1 more source

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay   +13 more
wiley   +1 more source

Prominent Movement Disorders in RNU2‐2‐Related Spliceosomopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Pediatric movement disorders often overlap with neurodevelopmental diseases, suggesting shared molecular mechanisms. Variants in small nuclear RNA (snRNA) genes encoding spliceosome components have recently been associated with neurodevelopmental disorders, termed “RNUopathies.” We analyzed genome sequencing data from 14 patients with ...
Magdalena Krygier   +6 more
wiley   +1 more source

Wavelets in numerical analysis and their quantitative properties [PDF]

open access: yes, 1997
We discuss various instances where wavelets on the interval serve as building blocks for extending wavelet methods to problems that are neither periodic nor defined on the whole Euclidean space.
Kunoth, A.   +5 more
core   +1 more source

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