Results 201 to 210 of about 568,578 (262)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Airborne respiratory aerosol transport and deposition in a two-person office using a novel diffusion-based numerical model. [PDF]

J Expo Sci Environ Epidemiol
Obeid S, White P, Rosati Rowe J, Ilacqua V, Rawat MS, Ferro AR, Ahmadi G.   +6 more
europepmc   +1 more source

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Numerical modeling for plasmonics

International Journal of Applied Electromagnetics and Mechanics, 2011
This contribution is a review paper, concerning mainly the research work made by the authors, about the numerical modeling, in the frequency domain, of both surface and bulk plasmon oscillations induced in metallic nanoparticles with arbitrary shapes by an external electromagnetic field.
G. Miano, G. Rubinacci, TAMBURRINO, Antonello   +2 more
openaire   +4 more sources

NUMERICAL MODELLING OF DISCONTINUA

Engineering Computations, 1992
Discrete element methods are numerical procedures for simulating the complete behaviour of systems of discrete, interacting bodies. Three important aspects of discrete element programs are examined: (1) the representation of contacts; (2) the representation of solid material; and (3) the scheme used to detect and revise the set of contacts.
PETER A. CUNDALL, ROGER D. HART
openaire   +1 more source

Numerical Modeling of Mudflows

Journal of Hydraulic Engineering, 1997
To predict mudflow dynamics a numerical model based on shallow-water equations is developed. Previous work has shown that mudflow behavior can be well represented by a Herschel-Bulkley model. In a laminar regime, generally observed in practice, a wall friction force expression has been theoretically deduced for steady uniform flows.
Laigle, D., Coussot, Philippe
openaire   +2 more sources

ON SMOOTH NUMERICAL MODEL

Acta Mathematica Scientia, 1994
An approach to approximate data by smooth numerical models is described. The idea seems to be ``\dots to fit a smooth numerical model to the data, instead of fitting a curve.'' Theoretical backgrounds are partially available and illustrative examples are discussed.
Xie, Litong, Liu, Jiazhuang
openaire   +2 more sources

Numerical Modeling of PMD

Journal of Optical and Fiber Communications Reports, 2004
A procedure for evaluating system performance considering all orders of polarization mode dispersion (PMD) is presented. The method provides engineering rules for computing system penalty introduced by PMD. Computer simulation of PMD induced penalty indicates that for generating a realistic system budget, effect of higher order PMD in presence of ...
D. Chowdhury, M. Mlejnek, Y. Mauro
openaire   +1 more source

Numerical Modelling

2018
This chapter deals with the problem of modelling the behaviour of massive concrete structures. In the last decades, the developments in the field of computational mechanics were significant, so nowadays several numerical techniques are available to this goal, depending on the scale level considered but also on which phenomena/processes are taken into ...
Pesavento F., Knoppik A., Šmilauer V., Briffaut. M., Rossi P.   +4 more
openaire   +2 more sources