Results 1 to 10 of about 267,557 (193)

A Review of Quantitative Systems Pharmacology Models of the Coagulation Cascade: Opportunities for Improved Usability [PDF]

Pharmaceutics, 2023
Despite the numerous therapeutic options to treat bleeding or thrombosis, a comprehensive quantitative mechanistic understanding of the effects of these and potential novel therapies is lacking. Recently, the quality of quantitative systems pharmacology (
Douglas Chung, Suruchi Bakshi, Piet H. van der Graaf   +2 more
doaj   +4 more sources

Best Practices to Maximize the Use and Reuse of Quantitative and Systems Pharmacology Models: Recommendations From the United Kingdom Quantitative and Systems Pharmacology Network [PDF]

CPT: Pharmacometrics & Systems Pharmacology, 2019
The lack of standardization in the way that quantitative and systems pharmacology (QSP) models are developed, tested, and documented hinders their reproducibility, reusability, and expansion or reduction to alternative contexts.
Lourdes Cucurull‐Sanchez, Michael J. Chappell, Vijayalakshmi Chelliah, S. Y. Amy Cheung, Gianne Derks, Mark Penney, Alex Phipps, Rahuman S. Malik‐Sheriff, Jon Timmis, Marcus J. Tindall, Piet H. van derGraaf, Paolo Vicini, James W. T. Yates   +12 more
doaj   +4 more sources

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies [PDF]

, 2018
Microphysiological systems (MPSs) are in vitro models that capture facets of in vivo organ function through use of specialized culture microenvironments, including 3D matrices and microperfusion.
Brij M. Bhushan, Catherine Communal, Christi D. Cook, Christian Maass, Collin D. Edington, Cynthia L. Stokes, David J. Hughes, David L. Trumper, Douglas A. Lauffenburger, Duncan Freake, Emily Geishecker, Emily Suter, Gaurav Rohatgi, Iris Lee, Jared Kirschner, Jason Velazquez, Jeremy J. Velazquez, Jiajie Yu, Jorge Valdez, Julia P. Papps, Laurie A. Boyer, Linda G. Griffith, Linda Stockdale, Luis R. Soenksen, Mario Gamboa, Matthew E. LaBarge, Michael Shockley, Murat Cirit, Nicholas Vann, Nikolaos Tsamandouras, Rebecca L. Carrier, Stephen Snyder, Steven R. Tannenbaum, Timothy Kassis, Tom Parent, Wen Li Kelly Chen, Xin Wang, Zhe Zhong   +37 more
core   +4 more sources

Quantitative Systems Pharmacology Models of Anti-Amyloid Treatments for Alzheimer's Disease: A Systematic Review. [PDF]

CPT Pharmacometrics Syst Pharmacol
Herriott L, Coles M, Fournier N, Gaffney E, Wagg J.   +4 more
europepmc   +4 more sources

Quantitative Systems Pharmacology Model to Predict Target Occupancy by Bruton Tyrosine Kinase Inhibitors in Patients With B‐Cell Malignancies [PDF]

CPT: Pharmacometrics & Systems Pharmacology
The effectiveness of Bruton tyrosine kinase (BTK) inhibitors is influenced by the level of BTK occupancy in target tissues. In randomized phase 3 studies, progression‐free survival (PFS) with zanubrutinib was superior to ibrutinib, whereas acalabrutinib ...
Oleg Demin Jr, Ying Ou, Galina Kolesova, Dmitry Shchelokov, Alexander Stepanov, Veronika Musatova, Sri Sahasranaman, Yating Zhao, Xiangyu Liu, Zhiyu Tang, William D. Hanley   +10 more
doaj   +2 more sources

Neuro-Dynamic Quantitative Systems Pharmacology (QSP) model describing Alzheimer's disease pathophysiology and treatment effects. [PDF]

NPJ Syst Biol Appl
Cao Y, Willis BA, Horie K, Wildsmith KR, Koyama A, Sachdev P, Penner N, Charil A, Irizarry M, Reyderman L.   +9 more
europepmc   +3 more sources

The promises of quantitative systems pharmacology modelling for drug development

Computational and Structural Biotechnology Journal, 2016
Recent growth in annual new therapeutic entity (NTE) approvals by the U.S. Food and Drug Administration (FDA) suggests a positive trend in current research and development (R&D) output.
V.R. Knight-Schrijver, V. Chelliah, L. Cucurull-Sanchez, N. Le Novère   +3 more
doaj   +3 more sources

Quantitative systems pharmacology of the eye: Tools and data for ocular QSP [PDF]

CPT: Pharmacometrics & Systems Pharmacology, 2023
Good eyesight belongs to the most‐valued attributes of health, and diseases of the eye are a significant healthcare burden. Case numbers are expected to further increase in the next decades due to an aging society.
Lars Kuepfer, Georg Fuellen, Thomas Stahnke   +2 more
doaj   +2 more sources

Quantitative systems pharmacology in the age of artificial intelligence [PDF]

CPT: Pharmacometrics & Systems Pharmacology, 2023
Benjamin Ribba
doaj   +2 more sources

Quantitative systems pharmacology model of GITR-mediated T cell dynamics in tumor microenvironment. [PDF]

CPT Pharmacometrics Syst Pharmacol, 2023
Ji Y, Madrasi K, Knee DA, Gruenbaum L, Apgar JF, Burke JM, Gomes B.   +6 more
europepmc   +3 more sources