The Emerging Discipline of Quantitative Systems Pharmacology [PDF]
Frontiers in Pharmacology, 2015 Quantitative Systems Pharmacology (QSP) has emerged recently as an approach that integrates knowledge coming from multiple disciplines including drug pharmacology, systems biology, physiology, mathematics and biochemistry. QSP was formally defined as a discipline and endorsed in the NIH White Paper (Sorger et al., 2011) in 2011.
Tarek A Leil, Sergey eErmakov
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The promises of quantitative systems pharmacology modelling for drug development [PDF]
Computational and Structural Biotechnology Journal, 2016 Recent growth in annual new therapeutic entity (NTE) approvals by the U.S. Food and Drug Administration (FDA) suggests a positive trend in current research and development (R&D) output.
V.R. Knight-Schrijver +3 more
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Best Practices to Maximize the Use and Reuse of Quantitative and Systems Pharmacology Models: Recommendations From the United Kingdom Quantitative and Systems Pharmacology Network [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2019 The lack of standardization in the way that quantitative and systems pharmacology (QSP) models are developed, tested, and documented hinders their reproducibility, reusability, and expansion or reduction to alternative contexts.
Lourdes Cucurull‐Sanchez +12 more
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Quantitative systems pharmacology in the age of artificial intelligence [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2023 Benjamin Ribba
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Pharmaceutics, 2023 Despite the numerous therapeutic options to treat bleeding or thrombosis, a comprehensive quantitative mechanistic understanding of the effects of these and potential novel therapies is lacking. Recently, the quality of quantitative systems pharmacology (
Douglas Chung +2 more
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Quantitative systems pharmacology in neuroscience: Novel methodologies and technologies [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2021 The development and application of quantitative systems pharmacology models in neuroscience have been modest relative to other fields, such as oncology and immunology, which may reflect the complexity of the brain.
Peter Bloomingdale +7 more
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Quantitative systems pharmacology model of B cell immune response in mouse [PDF]
Frontiers in ImmunologyB cell-mediated immunity plays a crucial role in long-term humoral protection. However, dysregulation of B cell development and differentiation may lead to the persistence of autoreactive clones, contributing to autoimmune diseases.
Yaroslav Ugolkov +10 more
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Industrialization of Quantitative Systems Pharmacology [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2019 Brian Topp +2 more
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Quantitative Systems Pharmacology Model to Predict Target Occupancy by Bruton Tyrosine Kinase Inhibitors in Patients With B‐Cell Malignancies [PDF]
CPT: Pharmacometrics & Systems PharmacologyThe effectiveness of Bruton tyrosine kinase (BTK) inhibitors is influenced by the level of BTK occupancy in target tissues. In randomized phase 3 studies, progression‐free survival (PFS) with zanubrutinib was superior to ibrutinib, whereas acalabrutinib ...
Oleg Demin Jr +10 more
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Quantitative Systems Pharmacology: A Regulatory Perspective on Translation [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2019 Issam Zineh
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