Quantitative systems pharmacology in the age of artificial intelligence [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2023 Benjamin Ribba
doaj +4 more sources
The promises of quantitative systems pharmacology modelling for drug development
Computational and Structural Biotechnology Journal, 2016 Recent growth in annual new therapeutic entity (NTE) approvals by the U.S. Food and Drug Administration (FDA) suggests a positive trend in current research and development (R&D) output.
V.R. Knight-Schrijver +3 more
doaj +5 more sources
Pharmaceutics, 2023 Despite the numerous therapeutic options to treat bleeding or thrombosis, a comprehensive quantitative mechanistic understanding of the effects of these and potential novel therapies is lacking. Recently, the quality of quantitative systems pharmacology (
Douglas Chung +2 more
doaj +3 more sources
Quantitative systems pharmacology in neuroscience: Novel methodologies and technologies [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2021 The development and application of quantitative systems pharmacology models in neuroscience have been modest relative to other fields, such as oncology and immunology, which may reflect the complexity of the brain.
Peter Bloomingdale +7 more
doaj +3 more sources
Quantitative systems pharmacology model of B cell immune response in mouse [PDF]
Frontiers in ImmunologyB cell-mediated immunity plays a crucial role in long-term humoral protection. However, dysregulation of B cell development and differentiation may lead to the persistence of autoreactive clones, contributing to autoimmune diseases.
Yaroslav Ugolkov +10 more
doaj +2 more sources
Quantitative Systems Pharmacology Model to Predict Target Occupancy by Bruton Tyrosine Kinase Inhibitors in Patients With B‐Cell Malignancies [PDF]
CPT: Pharmacometrics & Systems PharmacologyThe effectiveness of Bruton tyrosine kinase (BTK) inhibitors is influenced by the level of BTK occupancy in target tissues. In randomized phase 3 studies, progression‐free survival (PFS) with zanubrutinib was superior to ibrutinib, whereas acalabrutinib ...
Oleg Demin Jr +10 more
doaj +2 more sources
The Emerging Discipline of Quantitative Systems Pharmacology [PDF]
Frontiers in Pharmacology, 2015 Quantitative Systems Pharmacology (QSP) has emerged recently as an approach that integrates knowledge coming from multiple disciplines including drug pharmacology, systems biology, physiology, mathematics and biochemistry. QSP was formally defined as a discipline and endorsed in the NIH White Paper (Sorger et al., 2011) in 2011.
Tarek A Leil, Sergey eErmakov
doaj +7 more sources
Quantitative systems pharmacology of the eye: Tools and data for ocular QSP [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2023 Good eyesight belongs to the most‐valued attributes of health, and diseases of the eye are a significant healthcare burden. Case numbers are expected to further increase in the next decades due to an aging society.
Lars Kuepfer +2 more
doaj +2 more sources
Industrialization of Quantitative Systems Pharmacology [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2019 Brian Topp +2 more
doaj +3 more sources
Best Practices to Maximize the Use and Reuse of Quantitative and Systems Pharmacology Models: Recommendations From the United Kingdom Quantitative and Systems Pharmacology Network [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2019 The lack of standardization in the way that quantitative and systems pharmacology (QSP) models are developed, tested, and documented hinders their reproducibility, reusability, and expansion or reduction to alternative contexts.
Lourdes Cucurull‐Sanchez +12 more
doaj +6 more sources