Results 31 to 40 of about 12,009,787 (277)

Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration [PDF]

, 2015
Our goal in developing Microphysiological Systems (MPS) technology is to provide an improved approach for more predictive preclinical drug discovery via a highly integrated experimental/computational paradigm.
Griffith, Linda G, Wishnok, John S., Sarkar, Ujjal, Yu, Jiajie, Hughes, D. J., Cilfone, Nicholas A., Stokes, C. L., Cirit, Murat, Lauffenburger, Douglas A, Large, E. M., Tannenbaum, Steven R   +10 more
core   +1 more source

Quantitative Systems Pharmacology: A Framework for Context [PDF]

Current Pharmacology Reports, 2016
Quantitative Systems Pharmacology (QSP) is receiving increased attention. As the momentum builds and the expectations grow it is important to (re)assess and formalize the basic concepts and approaches. In this short review, I argue that QSP, in addition to enabling the rational integration of data and development of complex models, maybe more ...
openaire   +2 more sources

GPS for QSP: A Summary of the ACoP6 Symposium on Quantitative Systems Pharmacology and a Stage for Near-Term Efforts in the Field [PDF]

, 2016
Quantitative Systems Pharmacology (QSP) is experiencing increased application in the drug discovery and development process. Like its older sibling, systems biology, the QSP field is comprised of a mix of established disciplines and methods, from ...
Musante, CJ, Abernethy, DR, Allerheiligen, SR, Zager, MG, Lauffenburger, Douglas A   +4 more
core   +1 more source

Sources of inter-individual variability leading to significant changes in anti-PD-1 and anti-PD-L1 efficacy identified in mouse tumor models using a QSP framework

Frontiers in Pharmacology, 2022
While anti-PD-1 and anti-PD-L1 [anti-PD-(L)1] monotherapies are effective treatments for many types of cancer, high variability in patient responses is observed in clinical trials.
Jessica C. Leete, Jessica C. Leete, Michael G. Zager, Cynthia J. Musante, Blerta Shtylla, Wenlian Qiao, Wenlian Qiao   +6 more
doaj   +1 more source

Leveraging multi-omics data to empower quantitative systems pharmacology in immuno-oncology. [PDF]

Brief Bioinform
Arulraj T, Wang H, Ippolito A, Zhang S, Fertig EJ, Popel AS.   +5 more
europepmc   +2 more sources

Good Systems Network Meeting [PDF]

, 2020
You're viewing a past event from the Good Systems Grand Challenge team at The University of Texas at Austin that contains two presentations from May 19, 2020.Office of the VP for ...
Good Systems
core   +1 more source

Review of quantitative systems pharmacological modeling in thrombosis

Communications in Information and Systems, 2019
Hemostasis and thrombosis are often thought as two sides of the same clotting mechanism whereas hemostasis is a natural protective mechanism to prevent bleeding and thrombosis is a blood clot abnormally formulated inside a blood vessel, blocking the normal blood flow. The evidence to date suggests that at least arterial thrombosis results from the same
Limei Cheng, Guo-Wei Wei 0001, Tarek Leil   +2 more
openaire   +4 more sources

Pharmacometrics and Systems Pharmacology 2030

, 2020
In 2012, a new journal was launched from the ASCPT family, CPT: Pharmacometrics and Systems Pharmacology (PSP) as both quantitative system pharmacology (QSP) and pharmacometrics were growing fields in pharmacology, drug development, and drug use. In this
Eric Sobie, Mentre, France,, Duffull, Stephen,, Mager, Donald E.,, Vikram Sinha, Jonathan French, Lauffenburger, Douglas A.,, Donald E. Mager, Friberg, Lena E.,, Douglas A. Lauffenburger, French, Jonathan,, Stephen Duffull, Lang Li, Lena E. Friberg, Ping Zhao, France Mentré, Sobie, Eric,, Zhao, Ping,, Li, Lang,, Sinha, Vikram,   +19 more
core   +1 more source

Implementation of Quantitative and Systems Pharmacology in Large Pharma

CPT: Pharmacometrics & Systems Pharmacology, 2014
Quantitative and systems pharmacology concepts and tools are the foundation of the model‐informed drug development paradigm at Merck for integrating knowledge, enabling decisions, and enhancing submissions. Rigorous prioritization of modeling and simulation activities has enabled key drug development decisions and led to a high return on investment ...
Visser, S A G, de Alwis, D P, Kerbusch, T, Stone, J A, Allerheiligen, S R B   +4 more
openaire   +2 more sources

Pharmacodynamic Modeling to Evaluate the Impact of Cimetidine, an OCT2 Inhibitor, on the Anticancer Effects of Cisplatin

Cells, 2022
Despite potent anticancer activity, the clinical utilization of cisplatin is limited due to nephrotoxicity. As Organic Cation Transporter 2 (OCT2) has been shown to be one of the key transporters involved in the uptake of cisplatin into renal proximal ...
Hardik Mody, Tanaya R. Vaidya, Lawrence J. Lesko, Sihem Ait-Oudhia   +3 more
doaj   +1 more source