Results 31 to 40 of about 95,693 (243)

Implementation of Quantitative and Systems Pharmacology in Large Pharma

CPT: Pharmacometrics & Systems Pharmacology, 2014
Quantitative and systems pharmacology concepts and tools are the foundation of the model‐informed drug development paradigm at Merck for integrating knowledge, enabling decisions, and enhancing submissions. Rigorous prioritization of modeling and simulation activities has enabled key drug development decisions and led to a high return on investment ...
Visser, S A G, de Alwis, D P, Kerbusch, T, Stone, J A, Allerheiligen, S R B   +4 more
openaire   +2 more sources

PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle

Communications Biology, 2022
PDGF reduces expression of nitric oxide-sensitive soluble guanylyl cyclase (NO-sGC) through PI3K-P-Rex1-Rac1 signaling in vascular smooth muscle cells.
Staffan Hildebrand, Mohamed Ibrahim, Andreas Schlitzer, Lars Maegdefessel, Wilhelm Röll, Alexander Pfeifer   +5 more
doaj   +1 more source

Quantitative clinical pharmacology and patient-centered healthcare technologies: perspectives 2030

Регуляторные исследования и экспертиза лекарственных средств, 2022
One of the most promising trends in clinical pharmacology is pharmacometrics, a combination of pharmacology and statistics that implements quantitative approaches for characterising dose–response relationships and predicting the variability of these ...
V. I. Petrov, B. E. Tolkachev
doaj   +1 more source

Next-generation mammalian genetics toward organism-level systems biology

npj Systems Biology and Applications, 2017
Organism-level systems biology in mammals aims to identify, analyze, control, and design molecular and cellular networks executing various biological functions in mammals.
Etsuo A. Susaki, Hideki Ukai, Hiroki R. Ueda   +2 more
doaj   +1 more source

Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation. [PDF]

CPT: pharmacometrics & systems pharmacology, 2017
With the increased interest in the application of quantitative systems pharmacology (QSP) models within medicine research and development, there is an increasing need to formalize model development and verification aspects. In February 2016, a workshop was held at Roche Pharma Research and Early Development to focus discussions on two critical ...
Ribba, B., Grimm, H. P., Agoram, B., Davies, M. R., Gadkar, K., Niederer, S., Van Riel, N., Timmis, J., Van Der Graaf, P. H.   +8 more
openaire   +5 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Modeling and Simulation of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended‐Release and Immediate‐Release Formulations in Healthy Adults Using the Quantitative Systems Toxicology Software Platform DILIsym

CPT: Pharmacometrics & Systems Pharmacology
Acetaminophen (APAP) has been formulated as immediate‐, modified‐, and extended‐release tablets (APAP‐IR, ‐MR, and ‐ER, respectively). However, there was concern that APAP‐MR previously available in Europe could form a bezoar after a large overdose ...
James J. Beaudoin, Kyunghee Yang, Brett A. Howell, Zackary Kenz, Vinal V. Lakhani, Jeffrey L. Woodhead, John C. K. Lai, Cathy K. Gelotte, Sury Sista, Evren Atillasoy   +9 more
doaj   +1 more source

In vitro to clinical translation of combinatorial effects of doxorubicin and dexrazoxane in breast cancer: a mechanism-based pharmacokinetic/pharmacodynamic modeling approach

Frontiers in Pharmacology, 2023
Dexrazoxane (DEX) is the only drug clinically approved to treat Doxorubicin-induced cardiotoxicity (DIC), however its impact on the anticancer efficacy of DOX is not extensively studied.
Hardik Mody, Tanaya R. Vaidya, Jovin Lezeau, Kareem Taha, Sihem Ait-Oudhia   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source