Advancing pharmacometrics and systems pharmacology. [PDF]
, 2012 Pharmacometrics and systems pharmacology are emerging as principal quantitative sciences within drug development and experimental therapeutics. In recognition of the importance of pharmacometrics and systems pharmacology to the discipline of clinical ...
Terzic, Andre, Waldman, Scott A.
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Leveraging multi-omics data to empower quantitative systems pharmacology in immuno-oncology. [PDF]
Brief BioinformArulraj T +5 more
europepmc +2 more sources
NIH Support for the Emergence of Quantitative and Systems Pharmacology [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2013 The National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health (NIH) sponsored two workshops and the development of a white paper on the emergence of quantitative and systems pharmacology (QSP) as a discipline. In subsequent efforts to encourage this area, NIGMS modified existing research and training offerings.
Rogers, M, Lyster, P, Okita, R
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A quantitative systems pharmacology model for acute viral hepatitis B
Computational and Structural Biotechnology Journal, 2021 Hepatitis B liver infection is caused by hepatitis B virus (HBV) and represents a major global disease problem when it becomes chronic, as is the case for 80–90% of vertical or early life infections.
Eduardo Asín-Prieto +7 more
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GPS for QSP: A Summary of the ACoP6 Symposium on Quantitative Systems Pharmacology and a Stage for Near-Term Efforts in the Field [PDF]
, 2016 Quantitative Systems Pharmacology (QSP) is experiencing increased application in the drug discovery and development process. Like its older sibling, systems biology, the QSP field is comprised of a mix of established disciplines and methods, from ...
Abernethy, DR +4 more
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Towards personalized treatment of pain using a quantitative systems pharmacology approach [PDF]
, 2017 Pain is a complex biopsychosocial phenomenon of which the intensity, location and duration depends on various underlying components. Treatment of pain is associated with considerable inter-individual variability, and as such, requires a personalized ...
Dijk, M. (Monique) van +7 more
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Computational methods and applications for quantitative systems pharmacology [PDF]
Quantitative Biology, 2019 BackgroundQuantitative systems pharmacology (QSP) is an emerging discipline that integrates diverse data to quantitatively explore the interactions between d rugs and multi‐scale systems including small compounds, nucleic acids, proteins, pathways, cells, organs and disease processes.ResultsVarious computational methods such as ADME/T evaluation ...
Fuda Xie, Jiangyong Gu
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Biomarker-Drug and Liquid Biopsy Co-development for Disease Staging and Targeted Therapy: Cornerstones for Alzheimer's Precision Medicine and Pharmacology. [PDF]
, 2019 Systems biology studies have demonstrated that different (epi)genetic and pathophysiological alterations may be mapped onto a single tumor's clinical phenotype thereby revealing commonalities shared by cancers with divergent phenotypes.
Goetzl, Edward J +4 more
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Frontiers in Pharmacology, 2022 While anti-PD-1 and anti-PD-L1 [anti-PD-(L)1] monotherapies are effective treatments for many types of cancer, high variability in patient responses is observed in clinical trials.
Jessica C. Leete +6 more
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Clinical Pharmacology & Therapeutics: Past, Present, and Future. [PDF]
, 2017 Clinical Pharmacology & Therapeutics (CPT), the definitive and timely source for advances in human therapeutics, transcends the drug discovery, development, regulation, and utilization continuum to catalyze, evolve, and disseminate discipline ...
Terzic, Andre, Waldman, Scott A.
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