Results 41 to 50 of about 12,009,787 (277)

Prediction of Clinical Transporter‐Mediated Drug–Drug Interactions via Comeasurement of Pitavastatin and Eltrombopag in Human Hepatocyte Models

CPT: Pharmacometrics & Systems Pharmacology, 2020
A structurally identifiable micro‐rate constant mechanistic model was used to describe the interaction between pitavastatin and eltrombopag, with improved goodness‐of‐fit values through comeasurement of pitavastatin and eltrombopag.
Simon J. Carter, Bhavik Chouhan, Pradeep Sharma, Michael J. Chappell   +3 more
doaj   +1 more source

Quantitative System Pharmacology compiler collection (QSPcc), a general-purpose and systems biology focused model compiler

, 2020
Quantitative System Pharmacology compiler collection (QSPcc), a general-purpose and system-biology focused model ...
Alessio Paris, Susana Neves-Zaph, Corrado Priami, Rosario Lombardo, Luca Marchetti, Stefano Giampiccolo, Chanchala Kaddi, Danilo Tomasoni, Federico Reali, Giulia Simoni, Karim Azer   +10 more
core   +1 more source

PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle

Communications Biology, 2022
PDGF reduces expression of nitric oxide-sensitive soluble guanylyl cyclase (NO-sGC) through PI3K-P-Rex1-Rac1 signaling in vascular smooth muscle cells.
Staffan Hildebrand, Mohamed Ibrahim, Andreas Schlitzer, Lars Maegdefessel, Wilhelm Röll, Alexander Pfeifer   +5 more
doaj   +1 more source

Quantitative clinical pharmacology and patient-centered healthcare technologies: perspectives 2030

Регуляторные исследования и экспертиза лекарственных средств, 2022
One of the most promising trends in clinical pharmacology is pharmacometrics, a combination of pharmacology and statistics that implements quantitative approaches for characterising dose–response relationships and predicting the variability of these ...
V. I. Petrov, B. E. Tolkachev
doaj   +1 more source

Guest editorial: Pharmacology of female sexual behavior [PDF]

, 2014
Female sexual behavior has been studied over the last decades from many perspectives, e.g. biological function, endocrinology and brain mechanisms, but is has never developed into a big research area. However, in the last decade an increasing interest in
Sub BasicPharmacology&Psychopharmacology, Waldinger, Marcel, Olivier, Berend, Pharmacology, Sub General Pharmacology   +4 more
core   +1 more source

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies [PDF]

Scientific Reports, 2018
AbstractMicrophysiological systems (MPSs) are in vitro models that capture facets of in vivo organ function through use of specialized culture microenvironments, including 3D matrices and microperfusion. Here, we report an approach to co-culture multiple different MPSs linked together physiologically on re-useable, open-system microfluidic platforms ...
Collin D. Edington, Wen Li Kelly Chen, Emily Geishecker, Timothy Kassis, Luis R. Soenksen, Brij M. Bhushan, Duncan Freake, Jared Kirschner, Christian Maass, Nikolaos Tsamandouras, Jorge Valdez, Christi D. Cook, Tom Parent, Stephen Snyder, Jiajie Yu, Emily Suter, Michael Shockley, Jason Velazquez, Jeremy J. Velazquez, Linda Stockdale, Julia P. Papps, Iris Lee, Nicholas Vann, Mario Gamboa, Matthew E. LaBarge, Zhe Zhong, Xin Wang, Laurie A. Boyer, Douglas A. Lauffenburger, Rebecca L. Carrier, Catherine Communal, Steven R. Tannenbaum, Cynthia L. Stokes, David J. Hughes, Gaurav Rohatgi, David L. Trumper, Murat Cirit, Linda G. Griffith   +37 more
openaire   +4 more sources

Next-generation mammalian genetics toward organism-level systems biology

npj Systems Biology and Applications, 2017
Organism-level systems biology in mammals aims to identify, analyze, control, and design molecular and cellular networks executing various biological functions in mammals.
Etsuo A. Susaki, Hideki Ukai, Hiroki R. Ueda   +2 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Advancing pharmacometrics and systems pharmacology. [PDF]

, 2012
Pharmacometrics and systems pharmacology are emerging as principal quantitative sciences within drug development and experimental therapeutics. In recognition of the importance of pharmacometrics and systems pharmacology to the discipline of clinical ...
Waldman, Scott A., Terzic, Andre
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source