Results 1 to 10 of about 11,033 (240)

Adoption of Machine Learning in Pharmacometrics: An Overview of Recent Implementations and Their Considerations

Pharmaceutics, 2022
Pharmacometrics is a multidisciplinary field utilizing mathematical models of physiology, pharmacology, and disease to describe and quantify the interactions between medication and patient.
Alexander Janssen, Frank C Bennis
exaly   +3 more sources

Pharmacometrics in the Age of Large Language Models: A Vision of the Future [PDF]

Pharmaceutics
Background: Large Language Models (LLMs) have driven significant advances in artificial intelligence (AI), with transformative applications across numerous scientific fields, including biomedical research and drug development.
Elena Maria Tosca, Ludovica Aiello, Alessandro De Carlo, Paolo Magni   +3 more
doaj   +2 more sources

AI for NONMEM Coding in Pharmacometrics Research and Education: Shortcut or Pitfall? [PDF]

CPT: Pharmacometrics & Systems Pharmacology
Artificial intelligence (AI) is increasingly being explored as a tool to support pharmacometric modeling, particularly in addressing the coding challenges associated with NONMEM.
Wenhao Zheng, Wanbing Wang, Carl M. J. Kirkpatrick, Cornelia B. Landersdorfer, Huaxiu Yao, Jiawei Zhou   +5 more
doaj   +2 more sources

Tutorial on Causal Mediation Analysis for Pharmacometricians [PDF]

CPT: Pharmacometrics & Systems Pharmacology
Mediation analyses can support biomarker development by quantifying the part of the total treatment effect on clinical outcome that is mediated by the biomarker.
Sebastiaan Camiel Goulooze, Eleonora Marostica, Nelleke Snelder   +2 more
doaj   +2 more sources

Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation [PDF]

, 2018
During the 2017 Biennial meeting, the American Academy of Veterinary Pharmacology and Therapeutics hosted a 1‐day session on the influence of population variability on dose‐exposure‐response relationships. In Part I, we highlighted some of the sources of
Bailey, Bon, Cox, Darwich, Dorey, Duwal, Ette, Fink, Jamei, Jamei, Jeunesse, Li, Li, Lin, Maaland, Margolskee, Margolskee, Martinez, Martinez, Martinez, Mochel, Mochel, Mochel, Mochel, Mochel, Mould, Ogungbenro, Pade, Pade, Paulson, Pelligand, Rey, Rostami-Hodjegan, Sheiner, Silber, Sjögren, Toutain, Tsamandouras, T’jollyn, Willmann, Zhuang   +40 more
core   +14 more sources

Concept and utility of population pharmacokinetic and pharmacokinetic/pharmacodynamic models in drug development and clinical practice [PDF]

Arhiv za farmaciju, 2021
Due to frequent clinical trial failures and consequently fewer new drug approvals, the need for improvement in drug development has, to a certain extent, been met using model-based drug development.
Roganović Maša, Homšek Ana, Jovanović Marija, Topić-Vučenović Valentina, Ćulafić Milica, Miljković Branislava, Vučićević Katarina   +6 more
doaj   +1 more source

Regulatory utility of pharmacometrics in the development and evaluation of antimicrobial agents and its recent progress in China

CPT: Pharmacometrics & Systems Pharmacology, 2021
Pharmacometrics is an emerging science that interprets drug, disease, and trial information in a mathematical fashion to inform and facilitate efficient drug development and/or regulatory decisions.
Ming Zhao, Yuancheng Chen, Dong Yang, Cheng Lyu, Xingchen Bian, Xin Li, Weiyi Qiu, Zhiwei Huang, Zijian Hu, Jing Zhang   +9 more
doaj   +1 more source

Pharmacometrics: A New Era of Pharmacotherapy and Drug Development in Low- and Middle-Income Countries

Advances in Pharmacological and Pharmaceutical Sciences, 2023
Pharmacotherapy, in many cases, is practiced at a suboptimal level of performance in low- and middle-income countries (LMICs) although stupendous amounts of data are available regularly.
Muhammad Usman, Sitaram Khadka, Mohammad Saleem, Huma Rasheed, Bimal Kunwar, Moshin Ali   +5 more
doaj   +1 more source

Pharmacometrics approaches and its applications in diabetes: An overview

Journal of Pharmacy and Bioallied Sciences, 2021
Type 2 diabetes mellitus is the most prevalent and progressive in nature. As the time progress, the multifaceted complications and comorbidities associated to diabetes worsen in the form of macrovascular or microvascular or both. Pharmacometrics modeling
Sohail Aziz, Sabariah Noor Harun, Syed Azhar Syed Sulaiman, Siti Maisharah Sheikh Ghadzi   +3 more
doaj   +1 more source

Bayesian data assimilation to support informed decision-making in individualized chemotherapy [PDF]

, 2020
An essential component of therapeutic drug/biomarker monitoring (TDM) is to combine patient data with prior knowledge for model-based predictions of therapy outcomes.
de Wiljes, Jana, Hartung, Niklas, Huisinga, Wilhelm, Kloft, Charlotte, Maier, Corinna   +4 more
core   +2 more sources