Results 41 to 50 of about 11,033 (240)

A Mechanistic, Model-Based Approach to Safety Assessment in Clinical Development [PDF]

, 2012
Peer ...
Becker, T, Brosch, M, Görlitz, L, Hampe, J, Kuepfer, L, Laffert, B, Lippert, J, Meyer, M, Neuvonen, PJ, Niemi, M, Schafmayer, C, Schreiber, S, Siegmund, H.-U, von Kampen, O   +13 more
core   +1 more source

Utilization of data below the analytical limit of quantitation in pharmacokinetic analysis and modeling: promoting interdisciplinary debate [PDF]

, 2018
Traditionally, bioanalytical laboratories do not report actual concentrations for samples with results below the LOQ (BLQ) in pharmacokinetic studies.
Atholl Johnston, Autmizguine J, Beal S, Charlotte I S Barker, Chen X, Denti P, European Medicines Agency, Gopalakrishnan S, Hanno Evard, Ivo Leito, Jitmuang A, Joseph F Standing, Kalev Takkis, Karin Kipper, Keizer RJ, Klünder B, Koit Herodes, Lewis Couchman, Max Hecht, Ministry of Health Labour and Welfare, NordVal, Organisation for Economic Co-operation and Development, Pires de Mello CP, Rūta Veigure, US FDA, van der Laan LE, van Kesteren C, Worm AM   +27 more
core   +1 more source

Systematic Analysis of Quantitative Logic Model Ensembles Predicts Drug Combination Effects on Cell Signaling Networks [PDF]

, 2016
A major challenge in developing anticancer therapies is determining the efficacies of drugs and their combinations in physiologically relevant microenvironments. We describe here our application of “constrained fuzzy logic” (CFL) ensemble modeling of the
Clarke, David C., Lauffenburger, Douglas A, Morris, Melody Kay, Osimiri, Lindsey C.   +3 more
core   +1 more source

The clinical utility of pharmacometric models [PDF]

British Journal of Clinical Pharmacology, 2018
Pharmacometric models are powerful tools that can be used for a variety of purposes in clinical pharmacology, drug development and dose individualization. Lewis Sheiner famously described the process of learning versus confirming in the setting of drug development 1 and as applied to pharmacometrics.
Shaun S. Kumar, Eman Biltaji, Robert Bies, Catherine M. Sherwin   +3 more
openaire   +3 more sources

The Role of Pharmacometrics in Advancing the Therapies for Autoimmune Diseases

Pharmaceutics
Autoimmune diseases (AIDs) are a group of disorders in which the immune system attacks the body’s own tissues, leading to chronic inflammation and organ damage.
Artur Świerczek, Dominika Batko, Elżbieta Wyska   +2 more
doaj   +1 more source

Application of Physiologically‐Based and Population Pharmacokinetic Modeling for Dose Finding and Confirmation During the Pediatric Development of Moxifloxacin

CPT: Pharmacometrics & Systems Pharmacology, 2019
Moxifloxacin is a widely used fluoroquinolone for the treatment of complicated intra‐abdominal infections. We applied physiologically‐based pharmacokinetic (PBPK) and population pharmacokinetic (popPK) modeling to support dose selection in pediatric ...
Stefan Willmann, Matthias Frei, Gabriele Sutter, Katrin Coboeken, Thomas Wendl, Thomas Eissing, Jörg Lippert, Heino Stass   +7 more
doaj   +1 more source

Utilization of physiologically‐based pharmacokinetic model to assess disease‐mediated therapeutic protein‐disease‐drug interaction in immune‐mediated inflammatory diseases

Clinical and Translational Science, 2022
It is known that interleukin‐6 (IL‐6) can significantly modulate some key drug‐metabolizing enzymes, such as phase I cytochrome P450s (CYPs). In this study, a physiologically‐based pharmacokinetic (PBPK) model was developed to assess CYPs mediated ...
Lujing Wang, Yang Chen, Wangda Zhou, Xin Miao, Honghui Zhou   +4 more
doaj   +1 more source

An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation [PDF]

, 2018
This study uses a highly fidelity computational simulator of pulmonary physiology to evaluate the impact of a soluble guanylate cyclase (sGC) modulator on gas exchange in patients with chronic obstructive pulmonary disease (COPD) and pulmonary ...
Bates, Declan G., Becker-Pelster, Eva-Maria, Das, Anup, Hardman, Jonathan G., Saffaran, Sina, Schmitt, Walter, Wang, Wenfei, Weimann, Gerrit   +7 more
core   +3 more sources

Application of ggplot2 to Pharmacometric Graphics [PDF]

CPT: Pharmacometrics & Systems Pharmacology, 2013
Visualization is a powerful mechanism for extracting information from data. ggplot2 is a contributed visualization package in the R programming language, which creates publication‐quality statistical graphics in an efficient, elegant, and systematic manner.
Ito, K, Murphy, D
openaire   +2 more sources

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source