Results 31 to 40 of about 6,306 (210)
CPT: Pharmacometrics & Systems Pharmacology, 2019 Moxifloxacin is a widely used fluoroquinolone for the treatment of complicated intra‐abdominal infections. We applied physiologically‐based pharmacokinetic (PBPK) and population pharmacokinetic (popPK) modeling to support dose selection in pediatric ...
Stefan Willmann +7 more
doaj +1 more source
Informatics: The fuel for pharmacometric analysis [PDF]
The AAPS Journal, 2007 The current informal practice of pharmacometrics as a combination art and science makes it hard to appreciate the role that informatics can and should play in the future of the discipline and to comprehend the gaps that exist because of its absence. The development of pharmacometric informatics has important implications for expediting decision making ...
Thaddeus H, Grasela +6 more
openaire +2 more sources
British Journal of Clinical Pharmacology, EarlyView.Levofloxacin is a widely used antibiotic included in rifampicin‐resistant tuberculosis (RR‐TB) treatment. Data describing levofloxacin concentrations in breastmilk and infant exposure are limited. We analysed data from two South African studies of breastfeeding women receiving levofloxacin (750–1000 mg daily) for RR‐TB.
Sharon Sawe +9 more
wiley +1 more source
Concentration‐QTc Modeling of Ozanimod’s Major Active Metabolites in Adult Healthy Subjects
CPT: Pharmacometrics & Systems Pharmacology, 2021 Ozanimod, approved by regulatory agencies in multiple countries for the treatment of adults with relapsing multiple sclerosis, is a sphingosine 1‐phosphate (S1P) receptor modulator, which binds with high affinity selectively to S1P receptor subtypes 1 ...
Emily Briggs +4 more
doaj +1 more source
Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics
British Journal of Clinical Pharmacology, EarlyView.Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay +5 more
wiley +1 more source
The Many Flavors of Model‐Based Meta‐Analysis: Part I—Introduction and Landmark Data
CPT: Pharmacometrics & Systems Pharmacology, 2016 Meta‐analysis is an increasingly important aspect of drug development as companies look to benchmark their own compounds with the competition. There is scope to carry out a wide range of analyses addressing key research questions from preclinical through
M Boucher, M Bennetts
doaj +1 more source
Clinical and Translational Science, 2022 It is known that interleukin‐6 (IL‐6) can significantly modulate some key drug‐metabolizing enzymes, such as phase I cytochrome P450s (CYPs). In this study, a physiologically‐based pharmacokinetic (PBPK) model was developed to assess CYPs mediated ...
Lujing Wang +4 more
doaj +1 more source
Precision medicine in paediatrics: Progress and priorities
British Journal of Clinical Pharmacology, EarlyView.Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain +3 more
wiley +1 more source
A Multiple Imputation Workflow for Handling Missing Covariate Data in Pharmacometrics Modeling
CPT: Pharmacometrics & Systems PharmacologyCovariate missingness is a prevalent issue in pharmacometrics modeling. Incorrect handling of missing covariates can lead to biased parameter estimates, adversely affecting clinical practice and drug development dosing decisions.
My‐Luong Vuong +2 more
doaj +1 more source
Effective Visual Communication for the Quantitative Scientist
CPT: Pharmacometrics & Systems Pharmacology, 2019 Effective visual communication is a core competency for pharmacometricians, statisticians, and, more generally, any quantitative scientist. It is essential in every step of a quantitative workflow, from scoping to execution and communicating results and ...
Marc Vandemeulebroecke +3 more
doaj +1 more source