Results 11 to 20 of about 11,033 (240)

Metaheuristics for pharmacometrics [PDF]

CPT: Pharmacometrics & Systems Pharmacology, 2021
Metaheuristics is a powerful optimization tool that is increasingly used across disciplines to tackle general purpose optimization problems. Nature‐inspired metaheuristic algorithms is a subclass of metaheuristic algorithms and have been shown to be ...
Seongho Kim, Andrew C. Hooker, Yu Shi, Grace Hyun J. Kim, Weng Kee Wong   +4 more
doaj   +4 more sources

Advancing pharmacometrics and systems pharmacology. [PDF]

Clinical Pharmacology & Therapeutics, 2012
Pharmacometrics and systems pharmacology are emerging as principal quantitative sciences within drug development and experimental therapeutics. In recognition of the importance of pharmacometrics and systems pharmacology to the discipline of clinical ...
Terzic, Andre, Waldman, Scott A.
core   +5 more sources

Informatics: the fuel for pharmacometric analysis [PDF]

The AAPS Journal, 2007
The current informal practice of pharmacometrics as a combination art and science makes it hard to appreciate the role that informatics can and should play in the future of the discipline and to comprehend the gaps that exist because of its absence.
Brenda, Cirincione, Darcy, Hitchcock, Grasela Thaddeus, H., Jill, Fiedler-Kelly, Kathleen, Reitz, Smith, Barry, Susanne, Sardella   +6 more
core   +4 more sources

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics & Systems Pharmacology
Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik deGreef   +10 more
doaj   +2 more sources

Advancing Pharmacometrics in Africa: Insights and Perspectives From the 2025 Pharmacometrics Africa Conference. [PDF]

Clin Pharmacol Ther
Pharmacometrics (PMX) in Africa has transitioned from foundational capacity‐building to job creation, scientific leadership, regulatory influence, and health innovation. To accelerate this progress, the 2025 Pharmacometrics Africa Conference (PMXAC‐2025) convened key stakeholders to consolidate the continental PMX community, review progress in local ...
Adeagbo BA, Asiimwe IG, Chaba L, Kawuma AN, Ojara FW, Orherhe OM, Asiimwe SP, Pillay-Fuentes Lorente V, Sawe S, Phogole CM, Waitt C, Mouksassi S, Pillai GC.   +12 more
europepmc   +2 more sources

Pharmacometrics: Focus on the Patient [PDF]

CPT: Pharmacometrics & Systems Pharmacology, 2014
Pharmacometrics, whether using simple or complex models, has contributed to rational and efficient drug development,(1-3) with the main focus on early drug development.(4) This article describes why opportunities more directly focused on the patient abound in late stage development, illustrating the concept with three innovative examples which focus on
Dumitrescu, T Pene, Fossler, MJ, Schmith, VD   +2 more
openaire   +2 more sources

Variable or variate? A conundrum in pharmacometrics exposure–response models

CPT: Pharmacometrics & Systems Pharmacology, 2023
Key elements of scientific writing—consistency and clarity—can be compromised in case of inaccurate use of methodological terms, especially in complex and multidisciplinary scientific fields.
Ana‐Marija Grisic, Karthik Venkatakrishnan, Jonathan French, Akash Khandelwal   +3 more
doaj   +1 more source

Exposure‐response modeling for extrapolation from adult to pediatric patients who differ with respect to prognostic factors: Application to everolimus

CPT: Pharmacometrics & Systems Pharmacology, 2021
Pediatric extrapolation is essential for bringing treatments to the pediatric population, especially for indications where the recruitment of pediatric patients into clinical trials is difficult and where fully powered trials are impossible.
Thomas Dumortier, Günter Heimann, Martin Fink   +2 more
doaj   +1 more source

Modeling of Large Pharmacokinetic Data Using Nonlinear Mixed-Effects: A Paradigm Shift in Veterinary Pharmacology. A Case Study With Robenacoxib in Cats [PDF]

, 2016
The objective of this study was to model the pharmacokinetics (PKs) of robenacoxib in cats using a nonlinear mixed‐effects (NLME) approach, leveraging all available information collected from cats receiving robenacoxib s.c.
Beal, Benet, Dziak, Fink, Giraudel, Jung, King, Lainesse, Lascelles, Lavielle, Lavielle, Lees, Lehr, Martin-Jiménez, Mochel, Mochel, Pelligand, Pelligand, Savic, Sheiner, Sheiner, Sheiner, Silber, Thomasy, Toutain, Toutain, Toutain, Xu   +27 more
core   +2 more sources

A generic framework for the physiologically‐based pharmacokinetic platform qualification of PK‐Sim and its application to predicting cytochrome P450 3A4–mediated drug–drug interactions

CPT: Pharmacometrics & Systems Pharmacology, 2021
The success of applications of physiologically‐based pharmacokinetic (PBPK) modeling in drug development and drug labeling has triggered regulatory agencies to demand rigorous demonstration of the predictive capability of the specific PBPK platform for a
Sebastian Frechen, Juri Solodenko, Thomas Wendl, André Dallmann, Ibrahim Ince, Thorsten Lehr, Jörg Lippert, Rolf Burghaus   +7 more
doaj   +1 more source