Results 51 to 60 of about 267,706 (322)
PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle
Communications Biology, 2022 PDGF reduces expression of nitric oxide-sensitive soluble guanylyl cyclase (NO-sGC) through PI3K-P-Rex1-Rac1 signaling in vascular smooth muscle cells.
Staffan Hildebrand +5 more
doaj +1 more source
Quantitative clinical pharmacology and patient-centered healthcare technologies: perspectives 2030
Регуляторные исследования и экспертиза лекарственных средств, 2022 One of the most promising trends in clinical pharmacology is pharmacometrics, a combination of pharmacology and statistics that implements quantitative approaches for characterising dose–response relationships and predicting the variability of these ...
V. I. Petrov, B. E. Tolkachev
doaj +1 more source
G protein-coupled receptors not currently in the spotlight: free fatty acid receptor 2 and GPR35 [PDF]
, 2017 It is widely appreciated that G protein-coupled receptors have been the most successfully exploited class of targets for the development of small molecule medicines. Despite this, to date, less than 15% of the non-olfactory G protein-coupled receptors in
Milligan, Graeme
core +1 more source
Process Improvement for Maximized Therapeutic Innovation Outcome. [PDF]
, 2017 Deconvoluting key biological mechanisms forms the framework for therapeutic discovery. Strategies that enable effective translation of those insights along the development and regulatory path ultimately drive validated clinical application in patients ...
Terzic, Andre, Waldman, Scott A.
core +2 more sources
Next-generation mammalian genetics toward organism-level systems biology
npj Systems Biology and Applications, 2017 Organism-level systems biology in mammals aims to identify, analyze, control, and design molecular and cellular networks executing various biological functions in mammals.
Etsuo A. Susaki +2 more
doaj +1 more source
Analyzing Medication Documentation in Electronic Health Records: Dental Students’ Self-Reported Behaviors and Charting Practices [PDF]
, 2019 The aim of this two-part study was to assess third- and fourth-year dental students’ perceptions, self-reported behaviors, and actual charting practices regarding medication documentation in axiUm, the electronic health record (EHR) system.
Burcham, Wesley K. +3 more
core +1 more source
Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation. [PDF]
CPT: pharmacometrics & systems pharmacology, 2017 With the increased interest in the application of quantitative systems pharmacology (QSP) models within medicine research and development, there is an increasing need to formalize model development and verification aspects. In February 2016, a workshop was held at Roche Pharma Research and Early Development to focus discussions on two critical ...
Ribba, B. +8 more
openaire +5 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson +3 more
wiley +1 more source
Harvesting the Promise of AOPs: An assessment and recommendations [PDF]
, 2018 The Adverse Outcome Pathway (AOP) concept is a knowledge assembly and communication tool to facilitate the transparent translation of mechanistic information into outcomes meaningful to the regulatory assessment of chemicals.
Ankley, Gerald T. +8 more
core +4 more sources
A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho +7 more
wiley +1 more source