Results 71 to 80 of about 12,009,787 (277)

Host-directed therapies for tuberculosis: quantitative systems pharmacology approaches [PDF]

, 2021
Host-directed therapies (HDTs) that modulate host-pathogen interactions offer an innovative strategy to combat Mycobacterium tuberculosis (Mtb) infections.
Ottenhoff, T.H.M., Mehta, K.M., Mehta, K., Graaf, P.H. van der, Spaink, H.P., Hasselt, J.G.C. van   +5 more
core   +1 more source

Quantitative Systems Toxicology Modeling of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended‐Release and Immediate‐Release Formulations in Adults With Chronic Alcohol Use or Low Glutathione

CPT: Pharmacometrics & Systems Pharmacology
Acetaminophen (APAP), an over‐the‐counter analgesic and antipyretic, can cause hepatotoxicity when ingested in large overdoses. APAP has multiple formulations including immediate‐release (IR) and extended‐release (ER) preparations.
Kyunghee Yang, James J. Beaudoin, Brett A. Howell, James Mullin, Elham Amini, John C. K. Lai, Cathy K. Gelotte, Sury Sista, Evren Atillasoy   +8 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Systems Pharmacology‐Based Discovery of Natural Products for Precision Oncology Through Targeting Cancer Mutated Genes

, 2017
Massive cancer genomics data have facilitated the rapid revolution of a novel oncology drug discovery paradigm through targeting clinically relevant driver genes or mutations for the development of precision oncology.
Lin, P, Cheng, F, Fang, J, Zhao, Z, Wang, Q, Cai, C   +5 more
core   +1 more source

Systems pharmacology approach for prediction of pulmonary and systemic pharmacokinetics and receptor occupancy of inhaled drugs [PDF]

, 2016
Pulmonary drug disposition after inhalation is complex involving mechanisms, such as regional drug deposition, dissolution, and mucociliary clearance.
Chappell, M., Boger, Elin, Evans, N.,, P Ewing, Wigenborg, A.,, E Boger, Chappell, M. J. (Michael J.), A Wigenborg, Lundqvist, A.,, Boger, E., M Chappell, A Lundqvist, Evans, N., Chappell, M.,, Fridén, Markus,, Ewing, P., Boger, E.,, Evans, Neil D., N Evans, Ewing, P.,, Lundqvist, A., Friden, M., M Fridén, Fridén, Markus, Wigenborg, A.   +24 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences [PDF]

, 2019
Systems pharmacology integrates structural biological and pharmacological knowledge and experimental data, enabling dissection of organism and drug properties and providing excellent predictivity.
Sebastian Frechen, Riggs, Matthew,, Sjögren, Erik, Sergej Ramusovic, Edginton, Andrea,, Andreas Kovar, Jörg Lippert, Ramusovic, Sergej,, Sevestre, Michael,, Staab, Alexander,, Jan Schlender, Erik Sjögren, Lehr, Thorsten,, Valerie Nock, Teutonico, Donato, Riggs, Matthew, Edginton, Andrea, Karlsson, Mats, Peter Milligan, Stephan Schaller, Alexander Staab, Schlender, Jan,, Milligan, Peter,, Burghaus, Rolf,, Matthew Riggs, Frechen, Sebastian,, Schmidt, Stephan,, Burghaus, Rolf, Schlender, Jan, Kovar, Andreas,, Andrea Edginton, Schaller, Stephan, Karlsson, Mats,, Sjögren, Erik,, Lehr, Thorsten, Nock, Valerie, Nock, Valerie,, Teutonico, Donato,, Sevestre, Michael, Schmidt, Stephan, Solodenko, Juri, Thorsten Lehr, Rolf Burghaus, Ramusovic, Sergej, Michaël Sevestre, Milligan, Peter, Frechen, Sebastian, Donato Teutonico, Lippert, Joerg,, Schaller, Stephan,, Kovar, Andreas, Solodenko, Juri,, Stephan Schmidt, Mats Karlsson, Juri Solodenko, Lippert, Jörg, Staab, Alexander, Lippert, Joerg   +57 more
core   +3 more sources

Quantitative systems pharmacology of the eye: Tools and data for ocular QSP

CPT: Pharmacometrics & Systems Pharmacology, 2023
Good eyesight belongs to the most‐valued attributes of health, and diseases of the eye are a significant healthcare burden. Case numbers are expected to further increase in the next decades due to an aging society.
Lars Kuepfer, Georg Fuellen, Thomas Stahnke   +2 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source