Results 81 to 90 of about 12,009,787 (277)
Quantitative multi-objective verification for probabilistic systems [PDF]
, 2011 We present a verification framework for analysing multiple quantitative objectives of systems that exhibit both nondeterministic and stochastic behaviour.
Marta Kwiatkowska +17 more
core +1 more source
Quantitative systems pharmacology of interferon alpha administration: A multi-scale approach.
PLoS ONE, 2019 The therapeutic effect of a drug is governed by its pharmacokinetics which determine the downstream pharmacodynamic response within the cellular network. A complete understanding of the drug-effect relationship therefore requires multi-scale models which
Priyata Kalra +7 more
doaj +1 more source
A quantitative systems pharmacology (QSP) model for Pneumocystis treatment in mice [PDF]
BMC Systems Biology, 2018 The yeast-like fungi Pneumocystis, resides in lung alveoli and can cause a lethal infection known as Pneumocystis pneumonia (PCP) in hosts with impaired immune systems. Current therapies for PCP, such as trimethoprim-sulfamethoxazole (TMP-SMX), suffer from significant treatment failures and a multitude of serious side effects.
Guan-Sheng Liu +6 more
openaire +3 more sources
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
, 2021 This repository contains the QSP platform for TNBC developed by the Popel Systems Biology Laboratory https://popellab.johnshopkins.edu/. This version is published in Journal for ImmunoTherapy of Cancer: Wang H, Ma H, Sové RJ, Emens LA, Popel AS ...
Popel, Aleksander S. +4 more
core +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Reflecting on building quantitative systems pharmacology models from scratch
, 2023 Quantitative systems pharmacology (QSP) is an emerging field where mechanistic mathematical models are used by the pharmaceutical industry to develop new drug therapies.
Klinke, David
core +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Logic Modeling In Quantitative Systems Pharmacology (Journal Article)
CPT: Pharmacometrics and Systems Pharmacology, 2017 Here we present logic modeling as an approach to understand deregulation of signal transduction in disease and to characterize a drug’s mode of action. We discuss how to build a logic model from literature and experimental data and how to analyze the resulting model to obtain insights of relevance for systems pharmacology.
Traynard, Pauline +4 more
openaire +1 more source
Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source