Results 21 to 30 of about 12,009,787 (277)

Introduction to dynamical systems analysis in quantitative systems pharmacology: basic concepts and applications [PDF]

, 2020
Quantitative systems pharmacology (QSP) can be regarded as a hybrid of pharmacometrics and systems biology. Here, we introduce the basic concepts related to dynamical systems theory that are fundamental to the analysis of systems biology models ...
채동우
core   +1 more source

Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation. [PDF]

, 2017
With the increased interest in the application of quantitative systems pharmacology (QSP) models within medicine research and development, there is an increasing need to formalize model development and verification aspects.
Agoram, B., Davies, M. R., Gadkar, K., Ribba, B., van der Graaf, P. H., Niederer, S., van Riel, N., Timmis, Jonathan, Grimm, H. P.   +8 more
core   +7 more sources

Homeostasis, injury, and recovery dynamics at multiple scales in a self-organizing mouse intestinal crypt

eLife, 2023
The maintenance of the functional integrity of the intestinal epithelium requires a tight coordination between cell production, migration, and shedding along the crypt–villus axis.
Louis Gall, Carrie Duckworth, Ferran Jardi, Lieve Lammens, Aimee Parker, Ambra Bianco, Holly Kimko, David Mark Pritchard, Carmen Pin   +8 more
doaj   +1 more source

Broadening our understanding of genetic risk for scleroderma/systemic sclerosis by querying the chromatin architecture surrounding the risk haplotypes

BMC Medical Genomics, 2021
Background Genetic variants in the human leukocyte antigen (HLA) locus contribute to the risk for developing scleroderma/systemic sclerosis (SSc). However, there are other replicated loci that also contribute to genetic risk for SSc, and it is unknown ...
Kerry E. Poppenberg, Vincent M. Tutino, Evan Tarbell, James N. Jarvis   +3 more
doaj   +1 more source

Quantitative Systems Pharmacology: An Overview

International Journal of Pharma and Bio Sciences, 2023
Quantitative systems pharmacology (QSP) attempts to quantitatively resolve the complex mechanisms and interactions between physiology and medications. Systems biology-based mechanistic models describe biological pathways and their regulatory networks at molecular, cellular, tissue, organ, patient, and/or population levels.
null Dr. Virendra Kushwaha, null Dr. Pooja Agrawal, null Dr. Vipul Shukla, null Dr. Geeta Singh Rana   +3 more
openaire   +1 more source

Good Research Practice in Non-Clinical Pharmacology and Biomedicine [PDF]

, 2020
This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical ...

core   +1 more source

In vitro to clinical translational pharmacokinetic/pharmacodynamic modeling of doxorubicin (DOX) and dexrazoxane (DEX) interactions: Safety assessment and optimization

Scientific Reports, 2023
Despite high anticancer activity, doxorubicin (DOX)-induced cardiotoxicity (DIC) limits the extensive utility of DOX in a clinical setting. Amongst various strategies explored, dexrazoxane (DEX) remains the only cardioprotective agent to be approved for ...
Hardik Mody, Tanaya R. Vaidya, Sihem Ait-Oudhia   +2 more
doaj   +1 more source

A quantitative systems pharmacology model for acute viral hepatitis B

Computational and Structural Biotechnology Journal, 2021
Hepatitis B liver infection is caused by hepatitis B virus (HBV) and represents a major global disease problem when it becomes chronic, as is the case for 80–90% of vertical or early life infections.
Eduardo Asín-Prieto, Zinnia P. Parra-Guillen, José David Gómez Mantilla, Joris Vandenbossche, Kim Stuyckens, Xavier Woot de Trixhe, Juan José Perez-Ruixo, Iñaki F. Troconiz   +7 more
doaj   +1 more source

NIH Support for the Emergence of Quantitative and Systems Pharmacology [PDF]

CPT: Pharmacometrics & Systems Pharmacology, 2013
The National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health (NIH) sponsored two workshops and the development of a white paper on the emergence of quantitative and systems pharmacology (QSP) as a discipline. In subsequent efforts to encourage this area, NIGMS modified existing research and training offerings.
Rogers, M, Lyster, P, Okita, R
openaire   +2 more sources

Computational methods and applications for quantitative systems pharmacology [PDF]

Quantitative Biology, 2019
BackgroundQuantitative systems pharmacology (QSP) is an emerging discipline that integrates diverse data to quantitatively explore the interactions between d rugs and multi‐scale systems including small compounds, nucleic acids, proteins, pathways, cells, organs and disease processes.ResultsVarious computational methods such as ADME/T evaluation ...
Fuda Xie, Jiangyong Gu
openaire   +1 more source