Results 11 to 20 of about 12,009,787 (277)
A Quantitative Systems Pharmacology Perspective on the Importance of Parameter Identifiability [PDF]
Bulletin of Mathematical Biology, 2022 AbstractThere is an inherent tension in Quantitative Systems Pharmacology (QSP) between the need to incorporate mathematical descriptions of complex physiology and drug targets with the necessity of developing robust, predictive and well-constrained models.
Sher, A +8 more
openaire +6 more sources
Frequency‐Domain Response Analysis for Quantitative Systems Pharmacology Models [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2017 Drug dosing regimen can significantly impact drug effect and, thus, the success of treatments. Nevertheless, trial and error is still the most commonly used method by conventional pharmacometric approaches to optimize dosing regimen. In this tutorial, we utilize four distinct classes of quantitative systems pharmacology models to introduce frequency ...
Schulthess, P. +3 more
openaire +5 more sources
Virtual Populations for Quantitative Systems Pharmacology Models
, 2021 AbstractQuantitative systems pharmacology (QSP) places an emphasis on dynamic systems modeling, incorporating considerations from systems biology modeling and pharmacodynamics. The goal of QSP is often to quantitatively predict the effects of clinical therapeutics, their combinations, and their doses on clinical biomarkers and endpoints.
Yougan Cheng +5 more
openaire +4 more sources
A Quantitative Systems Pharmacology Perspective on Cancer Immunology [PDF]
Processes, 2015 The return on investment within the pharmaceutical industry has exhibited an exponential decline over the last several decades. Contemporary analysis suggests that the rate-limiting step associated with the drug discovery and development process is our limited understanding of the disease pathophysiology in humans that is targeted by a drug. Similar to
Christina Byrne-Hoffman, David II
openaire +2 more sources
Incorporating Placebo Response in Quantitative Systems Pharmacology Models [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2019 Evan B. Wang +3 more
doaj +3 more sources
Quantitative Systems Pharmacology Modeling Amid the Rise of Agentic AI [PDF]
CPT: Pharmacometrics & Systems PharmacologyJames Lu, Rajat Desikan
doaj +2 more sources
Development of bispecific T cell engagers: harnessing quantitative systems pharmacology. [PDF]
Trends Pharmacol Sci, 2023 Bispecific T cell engagers (bsTCEs) have emerged as a promising class of cancer immunotherapy. Several bsTCEs have achieved marketing approval; dozens more are under clinical investigation.
Qi T, Liao X, Cao Y.
europepmc +2 more sources
Frontiers in Systems Biology, 2023 Quantitative systems pharmacology (QSP) modeling has become an increasingly popular approach impacting our understanding of disease mechanisms and helping predict patients’ treatment responses to facilitate study design or development go/no-go decisions.
Meghna Verma +6 more
doaj +1 more source
A Framework for Simplification of Quantitative Systems Pharmacology Models in Clinical Pharmacology [PDF]
British Journal of Clinical Pharmacology, 2020 Quantitative systems pharmacology (QSP) is a relatively new discipline within modelling and simulation that has gained wide attention over the past few years. The application of QSP models spans drug-target identification and validation, through all drug development phases as well as clinical applications.
Abdallah Derbalah +4 more
openaire +2 more sources
Logic modeling in quantitative systems pharmacology
ISMB 2017, 2017 CPT: pharmacometrics & systems pharmacology 6(8), 499-511 (2017).
Traynard, Pauline +4 more
+7 more sources