Quantitative systems pharmacology in neuroscience: Novel methodologies and technologies [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2021 The development and application of quantitative systems pharmacology models in neuroscience have been modest relative to other fields, such as oncology and immunology, which may reflect the complexity of the brain.
Peter Bloomingdale +7 more
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The Emerging Discipline of Quantitative Systems Pharmacology [PDF]
Frontiers in Pharmacology, 2015 Quantitative Systems Pharmacology (QSP) has emerged recently as an approach that integrates knowledge coming from multiple disciplines including drug pharmacology, systems biology, physiology, mathematics and biochemistry. QSP was formally defined as a discipline and endorsed in the NIH White Paper (Sorger et al., 2011) in 2011.
Tarek A Leil, Sergey eErmakov
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Industrialization of Quantitative Systems Pharmacology [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2019 Brian Topp +2 more
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Best Practices to Maximize the Use and Reuse of Quantitative and Systems Pharmacology Models: Recommendations From the United Kingdom Quantitative and Systems Pharmacology Network [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2019 The lack of standardization in the way that quantitative and systems pharmacology (QSP) models are developed, tested, and documented hinders their reproducibility, reusability, and expansion or reduction to alternative contexts.
Lourdes Cucurull‐Sanchez +12 more
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Quantitative Systems Pharmacology: A Regulatory Perspective on Translation [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2019 Issam Zineh
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Logic modeling in quantitative systems pharmacology
ISMB 2017, 2017 CPT: pharmacometrics & systems pharmacology 6(8), 499-511 (2017).
Traynard, Pauline +4 more
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A Framework for Simplification of Quantitative Systems Pharmacology Models in Clinical Pharmacology [PDF]
British Journal of Clinical Pharmacology, 2020 Quantitative systems pharmacology (QSP) is a relatively new discipline within modelling and simulation that has gained wide attention over the past few years. The application of QSP models spans drug-target identification and validation, through all drug development phases as well as clinical applications.
Abdallah Derbalah +4 more
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Incorporating Placebo Response in Quantitative Systems Pharmacology Models [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2019 Evan B. Wang +3 more
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A Quantitative Systems Pharmacology Perspective on the Importance of Parameter Identifiability [PDF]
Bulletin of Mathematical Biology, 2022 AbstractThere is an inherent tension in Quantitative Systems Pharmacology (QSP) between the need to incorporate mathematical descriptions of complex physiology and drug targets with the necessity of developing robust, predictive and well-constrained models.
Sher, A +8 more
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Scientific Reports, 2023 Despite high anticancer activity, doxorubicin (DOX)-induced cardiotoxicity (DIC) limits the extensive utility of DOX in a clinical setting. Amongst various strategies explored, dexrazoxane (DEX) remains the only cardioprotective agent to be approved for ...
Hardik Mody +2 more
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