Quantitative systems pharmacology in neuroscience: Novel methodologies and technologies [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2021 The development and application of quantitative systems pharmacology models in neuroscience have been modest relative to other fields, such as oncology and immunology, which may reflect the complexity of the brain.
Peter Bloomingdale +7 more
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Quantitative Systems Pharmacology: A Framework for Context [PDF]
Current Pharmacology Reports, 2016 Quantitative Systems Pharmacology (QSP) is receiving increased attention. As the momentum builds and the expectations grow it is important to (re)assess and formalize the basic concepts and approaches. In this short review, I argue that QSP, in addition to enabling the rational integration of data and development of complex models, maybe more ...
Ioannis P. Androulakis
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The Emerging Discipline of Quantitative Systems Pharmacology [PDF]
Frontiers in Pharmacology, 2015 Quantitative Systems Pharmacology (QSP) has emerged recently as an approach that integrates knowledge coming from multiple disciplines including drug pharmacology, systems biology, physiology, mathematics and biochemistry. QSP was formally defined as a discipline and endorsed in the NIH White Paper (Sorger et al., 2011) in 2011.
Tarek A Leil, Sergey eErmakov
doaj +7 more sources
Industrialization of Quantitative Systems Pharmacology [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2019 Brian Topp +2 more
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Implementation of Quantitative and Systems Pharmacology in Large Pharma [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2014 Quantitative and systems pharmacology concepts and tools are the foundation of the model‐informed drug development paradigm at Merck for integrating knowledge, enabling decisions, and enhancing submissions. Rigorous prioritization of modeling and simulation activities has enabled key drug development decisions and led to a high return on investment ...
Sandra A. G. Visser +4 more
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Quantitative Systems Pharmacology Modeling Amid the Rise of Agentic AI [PDF]
CPT: Pharmacometrics & Systems PharmacologyJames Lu, Rajat Desikan
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Quantitative Systems Pharmacology: A Regulatory Perspective on Translation [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2019 Issam Zineh
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Logic modeling in quantitative systems pharmacology
ISMB 2017, 2017 CPT: pharmacometrics & systems pharmacology 6(8), 499-511 (2017).
Traynard, Pauline +4 more
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A mechanistic quantitative systems pharmacology model platform for translational efficacy evaluation and checkpoint combination design of bispecific immuno-modulatory antibodies. [PDF]
Front PharmacolXu Y +8 more
europepmc +2 more sources
Frontiers in Systems Biology, 2023 Quantitative systems pharmacology (QSP) modeling has become an increasingly popular approach impacting our understanding of disease mechanisms and helping predict patients’ treatment responses to facilitate study design or development go/no-go decisions.
Meghna Verma +6 more
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