Results 11 to 20 of about 95,693 (243)

Quantitative Systems Pharmacology: A Regulatory Perspective on Translation [PDF]

CPT: Pharmacometrics & Systems Pharmacology, 2019
Issam Zineh
doaj   +3 more sources

Quantitative Systems Pharmacology Modeling Amid the Rise of Agentic AI [PDF]

CPT: Pharmacometrics & Systems Pharmacology
James Lu, Rajat Desikan
doaj   +2 more sources

Logic modeling in quantitative systems pharmacology

ISMB 2017, 2017
CPT: pharmacometrics & systems pharmacology 6(8), 499-511 (2017).
Traynard, Pauline, Tobalina, Luis, Eduati, Federica, Calzone, Laurence, Saez-Rodriguez, Julio   +4 more
  +9 more sources

Quantitative systems modeling approaches towards model-informed drug development: Perspective through case studies

Frontiers in Systems Biology, 2023
Quantitative systems pharmacology (QSP) modeling has become an increasingly popular approach impacting our understanding of disease mechanisms and helping predict patients’ treatment responses to facilitate study design or development go/no-go decisions.
Meghna Verma, Louis Gall, Jacopo Biasetti, Giovanni Y. Di Veroli, Cesar Pichardo-Almarza, Megan A. Gibbs, Holly Kimko   +6 more
doaj   +1 more source

Incorporating Placebo Response in Quantitative Systems Pharmacology Models [PDF]

CPT: Pharmacometrics & Systems Pharmacology, 2019
Evan B. Wang, Lei Shen, Michael Heathman, Jason R. Chan   +3 more
doaj   +3 more sources

A Framework for Simplification of Quantitative Systems Pharmacology Models in Clinical Pharmacology [PDF]

British Journal of Clinical Pharmacology, 2020
Quantitative systems pharmacology (QSP) is a relatively new discipline within modelling and simulation that has gained wide attention over the past few years. The application of QSP models spans drug‐target identification and validation, through all drug development phases as well as clinical applications.
Abdallah Derbalah, Hesham Al‐Sallami, Chihiro Hasegawa, Abhishek Gulati, Stephen B. Duffull   +4 more
openaire   +2 more sources

Homeostasis, injury, and recovery dynamics at multiple scales in a self-organizing mouse intestinal crypt

eLife, 2023
The maintenance of the functional integrity of the intestinal epithelium requires a tight coordination between cell production, migration, and shedding along the crypt–villus axis.
Louis Gall, Carrie Duckworth, Ferran Jardi, Lieve Lammens, Aimee Parker, Ambra Bianco, Holly Kimko, David Mark Pritchard, Carmen Pin   +8 more
doaj   +1 more source

A Quantitative Systems Pharmacology Perspective on the Importance of Parameter Identifiability [PDF]

Bulletin of Mathematical Biology, 2022
AbstractThere is an inherent tension in Quantitative Systems Pharmacology (QSP) between the need to incorporate mathematical descriptions of complex physiology and drug targets with the necessity of developing robust, predictive and well-constrained models.
Sher, A, Niederer, SA, Mirams, GR, Kirpichnikova, A, Allen, R, Pathmanathan, P, Gavaghan, DJ, van der Graaf, PH, Noble, D   +8 more
openaire   +4 more sources

Broadening our understanding of genetic risk for scleroderma/systemic sclerosis by querying the chromatin architecture surrounding the risk haplotypes

BMC Medical Genomics, 2021
Background Genetic variants in the human leukocyte antigen (HLA) locus contribute to the risk for developing scleroderma/systemic sclerosis (SSc). However, there are other replicated loci that also contribute to genetic risk for SSc, and it is unknown ...
Kerry E. Poppenberg, Vincent M. Tutino, Evan Tarbell, James N. Jarvis   +3 more
doaj   +1 more source

In vitro to clinical translational pharmacokinetic/pharmacodynamic modeling of doxorubicin (DOX) and dexrazoxane (DEX) interactions: Safety assessment and optimization

Scientific Reports, 2023
Despite high anticancer activity, doxorubicin (DOX)-induced cardiotoxicity (DIC) limits the extensive utility of DOX in a clinical setting. Amongst various strategies explored, dexrazoxane (DEX) remains the only cardioprotective agent to be approved for ...
Hardik Mody, Tanaya R. Vaidya, Sihem Ait-Oudhia   +2 more
doaj   +1 more source