Results 241 to 250 of about 24,603,398 (314)

Experimental Testing, Manufacturing and Numerical Modeling of Composite and Sandwich Structures. [PDF]

Materials (Basel)
Camplho RDSG.
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Numerical Modeling of Multiphysics Constitutive Relations Governing Water Migration into Variably Saturated Sorptive Shale. [PDF]

ACS Omega
Mi K, Xu Y, Lei Y, Wang J, Shen P, Zhang X.   +5 more
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Reinforced Fill Structure with Alternative Fill Materials: An Application of Geogrid Creep Strain Analysis Using Numerical Modeling. [PDF]

Materials (Basel)
Khan AR, Di Emidio G.
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Advances in Microfluidic Systems and Numerical Modeling in Biomedical Applications: A Review. [PDF]

Micromachines (Basel)
Ferreira M, Carvalho V, Ribeiro J, Lima RA, Teixeira S, Pinho D.   +5 more
europepmc   +1 more source

Application of Numerical Modeling and Finite Element Analysis in Fused Filament Fabrication: A Review. [PDF]

Materials (Basel)
Behseresht S, Park YH, Love A, Valdez Pastrana OA.   +3 more
europepmc   +1 more source

Numerical Modeling Reveals That Resistant Western Corn Rootworm Are Stronger Fliers than Their Susceptible Conspecifics. [PDF]

Insects
Mikac KM, Lemic D, Pajač Živković I, Dominguez Davila JH.   +3 more
europepmc   +1 more source

Numerical modeling assisting in surgical treatment of total anomalous pulmonary venous connection in children. [PDF]

World J Pediatr Surg
Jin J, Gu K, Liang J, Yu J, Fan X.
europepmc   +1 more source