Results 41 to 50 of about 937,465 (286)

Essentials of numerical nonsmooth optimization [PDF]

4OR, 2019
AbstractApproximately sixty years ago two seminal findings, the cutting plane and the subgradient methods, radically changed the landscape of mathematical programming. They provided, for the first time, the practical chance to optimize real functions of several variables characterized by kinks, namely by discontinuities in their derivatives.
Gaudioso, Manlio, Giallombardo, Giovanni, Miglionico, Giovanna   +2 more
openaire   +2 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

An α-Model Parametrization Algorithm for Optimization with Differential-Algebraic Equations

Applied Sciences, 2022
An optimization task with nonlinear differential-algebraic equations (DAEs) was approached. In special cases in heat and mass transfer engineering, a classical direct shooting approach cannot provide a solution of the DAE system, even in a relatively ...
Paweł Drąg
doaj   +1 more source

Global optimization of complex optical structures using Baysian optimization based on Gaussian processes

, 2017
Numerical simulation of complex optical structures enables their optimization with respect to specific objectives. Often, optimization is done by multiple successive parameter scans, which are time consuming and computationally expensive.
Burger, S., Rockstuhl, C., Santiago, X. Garcia, Schneider, P. -I.   +3 more
core   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

An Adaptive Whale Optimization Algorithm Using Gaussian Distribution Strategies and Its Application in Heterogeneous UCAVs Task Allocation

IEEE Access, 2019
To overcome the defect of whale optimization algorithm (WOA) being easily fallen into local optimum caused by the ill-distribution of solutions, this paper explores an adaptive WOA variant using Gaussian distribution strategies (GDSs), named GDS-WOA.
Yintong Li, Tong Han, Hui Zhao, Hanjie Gao   +3 more
doaj   +1 more source

Fireworks explosion boosted Harris Hawks optimization for numerical optimization: Case of classifying the severity of COVID-19

Frontiers in Neuroinformatics, 2023
Harris Hawks optimization (HHO) is a swarm optimization approach capable of handling a broad range of optimization problems. HHO, on the other hand, is commonly plagued by inadequate exploitation and a sluggish rate of convergence for certain numerical ...
Mingjing Wang, Mingjing Wang, Long Chen, Long Chen, Ali Asghar Heidari, Huiling Chen   +5 more
doaj   +1 more source

Numerical optimization of passive chaotic micromixers [PDF]

, 2011
This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
3rd Micro and Nano Flows Conference (MNF2011), Harting, J, Narváez, A, Sarkar, A   +3 more
core  

Benchmarking five global optimization approaches for nano-optical shape optimization and parameter reconstruction

, 2019
Numerical optimization is an important tool in the field of computational physics in general and in nano-optics in specific. It has attracted attention with the increase in complexity of structures that can be realized with nowadays nano-fabrication ...
Burger, Sven, Hammerschmidt, Martin, Rockstuhl, Carsten, Santiago, Xavier Garcia, Schneider, Philipp-Immanuel, Soltwisch, Victor   +5 more
core   +1 more source