Results 61 to 70 of about 3,753,786 (301)
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Multibaseline Polarimetric SAR Interferometry Coherence Optimization [PDF]
, 2008 This letter analyzes different approaches for polarimetric optimization of multibaseline (MB) interferometric coherences. Two general methods are developed to simultaneously optimize coherences for more than two data sets. The first method provides every
Ferro-Famil, Laurent +2 more
core +1 more source
Numerical Optimization Methods for Metasurfaces
Laser & Photonics Reviews, 2020 AbstractIn recent years, metasurfaces have emerged as revolutionary tools to manipulate the behavior of light at the nanoscale. These devices consist of nanostructures defined within a single layer of metal or dielectric materials, and they offer unprecedented control over the optical properties of light, leading to previously unattainable applications
Elsawy, Mahmoud +4 more
openaire +3 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Meta-Model Framework for Surrogate-Based Parameter Estimation in Dynamical Systems
IEEE Access, 2019 The central task in modeling complex dynamical systems is parameter estimation. This task is an optimization task that involves numerous evaluations of a computationally expensive objective function.
Ziga Luksic +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Aerodynamic Shape Optimization Using the Discrete Adjoint of the Navier-Stokes Equations: Applications Toward Complex 3D Configutations [PDF]
, 2009 Within the next few years, numerical shape optimization based on high fidelity methods is likely to play a strategic role in future aircraft design. In this context, suitable tools have to be developed for solving aerodynamic shape optimization problems,
Dwight, Richard P. +5 more
core +1 more source
Frontiers in Microbiology, 2018 Increasing the final titer of a multi-gene metabolic pathway can be viewed as a multivariate optimization problem. While numerous multivariate optimization algorithms exist, few are specifically designed to accommodate the constraints posed by genetic ...
Stephen C. Heinsch +5 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Flexible numerical optimization with ensmallen
CoRR, 2020 https://ensmallen.org/
Ryan R. Curtin +5 more
openaire +3 more sources