Results 61 to 70 of about 245,507 (312)

Logistic Regression Based on Individual-Level Predictors and Aggregate-Level Responses

open access: yesMathematics, 2023
We propose estimation methods to conduct logistic regression based on individual-level predictors and aggregate-level responses. We derive the likelihood of logistic models in this situation and proposed estimators with different optimization methods ...
Zheng Xu
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

A Quantum-Based Beetle Swarm Optimization Algorithm for Numerical Optimization

open access: yesApplied Sciences, 2023
The beetle antennae search (BAS) algorithm is an outstanding representative of swarm intelligence algorithms. However, the BAS algorithm still suffers from the deficiency of not being able to handle high-dimensional variables.
Lin Yu, Jieqi Ren, Jie Zhang
doaj   +1 more source

Three-dimensional large-scale aerodynamic shape optimization based on shape calculus

open access: yes, 2013
Large-scale three-dimensional aerodynamic shape optimization based on the compressible Euler equations is considered. Shape calculus is used to derive an exact surface formulation of the gradients, enabling the computation of shape gradient information ...
Schmidt, Stephan   +4 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A new continuous optimization method of standardized cubic permanent magnets for stellarators

open access: yesNuclear Fusion
Stellarator configurations can be realized using permanent magnets in combination with tokamak-like planar coils. From the perspective of engineering feasibility and cost-effectiveness, using standardized cubic permanent magnets with a finite number of ...
Xiangyu Zhang   +7 more
doaj   +1 more source

Flexible numerical optimization with ensmallen

open access: yesCoRR, 2020
https://ensmallen.org/
Ryan R. Curtin   +5 more
openaire   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Enhancing C2 and C3 coherency resolutions through optimizing semblance-based functions [PDF]

open access: yesGeofísica Internacional, 2007
Apparent dips from 3-D reflectors are calculated by maximizing the semblance-based coherency (C2) by numerical optimization techniques. This maximization was done by means of searching through a tessellation of the apparent dips domain, and by ...
J.O. Campos-Enriquez, F. Reyes-Ramos
doaj  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

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