Results 81 to 90 of about 245,507 (312)

Numerical Optimization of the Coil Geometry in a Large-Scale Levitation Melting Device—With Titanium as a Case Study

Energies
Electromagnetic levitation melting offers the opportunity for the energy-efficient processing of reactive and high-purity metals. This paper concerns a new levitator design that significantly expands the achievable mass of molten metal by processing a ...
Sławomir Golak, Radosław Zybała
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

High-Fidelity Optimization Framework for Helicopter Rotors

, 2009
An optimization framework for helicopter rotors based on high-fidelity coupled CFD/CSM analyses is presented. For this purpose the optimization software DAKOTA has been linked to a parametric geometry unit, a mesh generation unit and a fluid-structure ...
Imiela, Manfred
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Optimization of Water Based Drilling Fluid Produced Using Modified Nigerian Bentonite and Natural Biopolymers: Reduced experiment and Response Surface Methodology [PDF]

Iranian Journal of Chemical Engineering, 2019
Research has shown that many Bentonite in Nigeria are unsuitable for oil well drilling in their natural states. Their modification and blends with some additives could increase the yield and boost their suitability.
A. Arinkoola, T. Salawudeen, K. Salam, M. Jimoh, Z. Atitebi, G. Abidemi   +5 more
doaj  

Bacterial foraging optimization algorithm with particle swarm optimization strategy for global numerical optimization

, 2009
In 2002, K. M. Passino proposed Bacterial Foraging Optimization Algorithm (BFOA) for distributed optimization and control. One of the major driving forces of BFOA is the chemotactic movement of a virtual bacterium that models a trial solution of the ...
Guo HF(郭海峰), Chang CG(常春光), Zhu YL(朱云龙), Shen H(申海), Zhou XM(周小明)   +4 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Symbolic Noise Analysis Approach to Computational Hardware Optimization [PDF]

, 2008
This paper addresses the problem of computational error modeling and analysis. Choosing different word-lengths for each functional unit in hardware implementations of numerical algorithms always results in an optimization problem of trading computational
Ahmadi, Arash, Zwolinski, Mark, Arash Ahmadi, Mark Zwolinski   +3 more
core   +1 more source