Results 101 to 110 of about 937,465 (286)

Finding Optimal Zone II Settings for Distance Relays in Coordination With Directional Overcurrent Relays Using QCQP Algorithm

IEEE Access
This paper introduces a deterministic method to address coordination challenges between distance relays (DS) and directional overcurrent relays (DOR) by employing quadratic programming with quadratic constraints (QCQP).
N. Praneeth, S. T. P. Srinivas, Alivelu M. Parimi, J. Ankamma Rao, Getie Tesfaye Zelie   +4 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

NUMERICAL ANALYSIS AND OPTIMIZATION OF SUPPORTING SYSTEM FOR FOUR HORNS ASSEMBLY [PDF]

Scientific Journal of Silesian University of Technology. Series Transport, 2014
In the paper the supporting frame for four horns design for the High Intensity Neutrino Project EURONu is proposed and numerically investigated. The whole set is designed for the experimental investigations of the neutrino oscillations.
Bogdan SZYBIŃSKI
doaj  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Solving Dynamic Stochastic Optimization Problems Using the Method of Endogenous Gridpoints [PDF]

Numerical Optimization; Dynamic Programming; Precautionary ...
Christopher D. Carroll
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Plasmonic Nanoprism Distributions to Promote Enhanced and Uniform Energy Deposition in Passive and Active Targets

Nanomaterials
Passive and active targets, both implanted with gold nanoprisms, were designed to achieve enhanced, uniform power absorption during two-sided illumination with short laser pulses.
Dávid Vass, Emese Tóth, András Szenes, Balázs Bánhelyi, István Papp, Tamás Sándor Biró, László Pál Csernai, Norbert Kroó, Mária Csete   +8 more
doaj   +1 more source

Numerical Optimization to AI, and Back

Proceedings of the AAAI Conference on Artificial Intelligence, 2019
The impact of numerical optimization on modern data analysis has been quite significant. Today, these methods lie at the heart of most statistical machine learning applications in domains spanning genomics, finance and medicine. The expanding scope of these applications (and the complexity of the associated data) has continued to raise the expectations
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source