Results 121 to 130 of about 245,507 (312)

Optimization of acoustic response : a numerical and experimental comparison

, 2000
Acoustic optimization within structural dynamics involves automatic changes of structural design variables such as geometric dimensions, shell thickness, material parameters, fiber density and orientation angles, and others to obtain minimum noise or a ...
Tinnsten, Mats,
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Determining Gas Condensate Composition Using Well Test Data and Optimization Algorithms

Georesursy
This study proposes an optimization-based approach to determine the actual fluid composition of gas condensate reservoirs when obtaining representative samples are impossible.
B. N. Starovoytova, B. K. Imomvazarov, A. N. Baykin   +2 more
doaj   +1 more source

Stress-constrained topology optimization using the constrained natural element method [PDF]

This paper presents a topology optimization framework to achieve volume minimization with Crossland fatigue constraints under proportional loading using the Constrained Natural Element Method.
CHEN, Yanda, MONTEIRO, Eric, Monteiro, E., FAVIER, Véronique, KOUTIRI, Imade   +4 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

LSEWOA: An Enhanced Whale Optimization Algorithm with Multi-Strategy for Numerical and Engineering Design Optimization Problems

Sensors
The Whale Optimization Algorithm (WOA) is a bio-inspired metaheuristic algorithm known for its simple structure and ease of implementation. However, WOA suffers from issues such as premature convergence, low population diversity in the later stages of ...
Junhao Wei, Yanzhao Gu, Yuzheng Yan, Zikun Li, Baili Lu, Shirou Pan, Ngai Cheong   +6 more
doaj   +1 more source

Numerical Optimization for Tensor Disentanglement

CoRR
Tensor networks provide compact and scalable representations of high-dimensional data, enabling efficient computation in fields such as quantum physics, numerical partial differential equations (PDEs), and machine learning. This paper focuses on tensor disentangling, the task of identifying transformations that reduce bond dimensions by exploiting ...
Julia Wei, Alec Dektor, Chungen Shen, Zaiwen Wen, Chao Yang   +4 more
openaire   +2 more sources

Urban VANET performance optimization [PDF]

Urban VANET (Vehicular Ad hoc NETworks) performance optimization concerns the improvement of wireless signal quality between two arbitrary selected nodes moving within along city streets.
Yu, Xiang (Researcher in engineering)
core