Results 141 to 150 of about 245,507 (312)

A Novel Magnetic Update Operator for Quantum Evolutionary Algorithms

open access: yes, 2010
Quantum Evolutionary Algorithms (QEA) are novel algorithms proposed for class of combinatorial optimization problems. The probabilistic representation of possible solutions in QEA helps the q-individuals to represent all the search space simultaneously ...
Tayarani Najaran, Mohammad   +1 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

The Influence of Optimization Algorithm on Suction Muffler Design

open access: yes, 2012
The standards for refrigerators energy consumption are increasing faster in the recent past years, so, the situation demands compressor with a higher efficiency level.
Wajczyk, Talita, Link, Rodrigo
core  

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

An extension and numerical analysis of the Hohmann spiral transfer

open access: yes, 2012
This paper extends previous work on the Hohmann Transfer Spiral (HST) by introducing a plane change into the analysis. An analytical expression determining the critical specific impulse incorporating a plane change is derived for both a circular and ...
Macdonald, Malcolm, Owens, Steven Robert
core  

Differential Evolution with Enhanced Abilities for Adaptation Applied to Heterogeneous Numerical Optimization [PDF]

open access: yes, 2012
This article presents an exploration of Differential Evolution (DE) algorithm with enhanced adaptability. The main purpose of this study is to identify how this search method can cope with changes of the number of variables of a hard design test, unaided.
Lazarova, Mariya, Penev, Kalin
core  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

High-Performance Numerical Software for Control

open access: yes, 2004
The article "High-Performance Numerical Software for Control" concerns the development of quality software for control applications that perform efficiently and reliably on today'S modern computing machines.
Delebecque, Francoise   +4 more
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

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