Results 141 to 150 of about 937,465 (286)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

A Geometric Whale Optimization Algorithm with Triangular Flight for Numerical Optimization and Engineering Design. [PDF]

Sci Rep
Wei J, Zhang R, Gu Y, Zhu W, Li Y, Li Z, Wu S, Wang Z, Cheong N, Im SK, Wang Y, Yang X.   +11 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Numerical Optimization and Experimental Validation of Finite Perforated Cellular Panels for Vibration Reduction. [PDF]

Materials (Basel)
Sáez B, Meruane V, Fernández R, Saavedra Flores EI.   +3 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Comprehensive Learning-Enhanced Educational Competition Optimizer for Numerical Optimization and Reservoir Production Optimization. [PDF]

Biomimetics (Basel)
Li S, Luo J.
europepmc   +1 more source

AOBLMOA: A Hybrid Biomimetic Optimization Algorithm for Numerical Optimization and Engineering Design Problems. [PDF]

Biomimetics (Basel), 2023
Zhao Y, Huang C, Zhang M, Cui Y.
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Cauchy distribution optimizer for photovoltaic model parameter extraction and numerical optimization. [PDF]

Sci Rep
Fang D, Zhou Q, Jun Y, Guo S, Guo P.
europepmc   +1 more source

Red-tailed hawk algorithm for numerical optimization and real-world problems. [PDF]

Sci Rep, 2023
Ferahtia S, Houari A, Rezk H, Djerioui A, Machmoum M, Motahhir S, Ait-Ahmed M.   +6 more
europepmc   +1 more source