Results 151 to 160 of about 937,465 (286)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

An enhanced neural network algorithm and its applications for numerical optimization and parameter extraction of photovoltaic models. [PDF]

Sci Rep
Chi A, Mirjalili S, Zhang Y.
europepmc   +1 more source

A multi-strategy improved tree-seed algorithm for numerical optimization and engineering optimization problems. [PDF]

Sci Rep, 2023
Liu J, Hou Y, Li Y, Zhou H.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Experimental and numerical optimization of pressurized air vessel performance for water hammer mitigation. [PDF]

Sci Rep
Hamed AM, Abdulaziz AM.
europepmc   +1 more source

Numerical optimization and performance evaluation of ZnPC:PC70BM based dye-sensitized solar cell. [PDF]

Sci Rep, 2023
Nowsherwan GA, Iqbal MA, Rehman SU, Zaib A, Sadiq MI, Dogar MA, Azhar M, Maidin SS, Hussain SS, Morsy K, Choi JR.   +10 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Numerical Optimization [PDF]

, 1988
Luciano Misici, Francesco Zirilli
openaire   +1 more source

Enhanced crested porcupine optimizer for numerical optimization and wireless sensor network deployment. [PDF]

Sci Rep
Zhao F, Li Z, Guo P, Zhao A, Fu Y.
europepmc   +1 more source