Results 71 to 80 of about 245,507 (312)
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Application of Exact Newton Optimisation to the Maximum Likelihood Ensemble Filter
Tellus: Series A, Dynamic Meteorology and OceanographyThe Newton method is used for optimisation in the maximum likelihood ensemble filter (MLEF) to improve analysis convergence and accuracy. The proposed method is compared against the original method using the conjugate gradient (CG) method preconditioned ...
Takeshi Enomoto, Saori Nakashita
doaj +1 more source
Optimization Library for Interactive Multi-Criteria Optimization Tasks
, 2012 The commercial library Optimization 2.1 for interactive multi-criteria optimization tasks has been released along with Dymola 2013. The library offers several numerical optimization algorithms for solving different kinds of optimization tasks.
Pfeiffer, Andreas, Andreas Pfeiffer
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Multi-Objective Numerical Optimization Applied to Aircraft Design
, 2008 Aircraft design is a very complex process because several disciplines are involved at the same time: aerodynamics, structures, performances, propulsion, costs. From this point of view, the real aircraft is a compromise between several requirements, often
Grasso, Francesco
core
A geometry optimization framework for photonic crystal design
, 2012 The performance of photonic crystal devices can depend strongly on their geometry. Alas, their fundamental physics offers relatively little by way of pointers in terms of optimum shapes, so numerical design search techniques must be used in an attempt to
Thomas, K.S. +11 more
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Multibaseline Polarimetric SAR Interferometry Coherence Optimization
, 2008 This letter analyzes different approaches for polarimetric optimization of multibaseline (MB) interferometric coherences. Two general methods are developed to simultaneously optimize coherences for more than two data sets. The first method provides every
Ferro-Famil, Laurent +2 more
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source