Results 71 to 80 of about 3,753,786 (301)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Recent advances in surrogate-based optimization [PDF]

, 2009
The evaluation of aerospace designs is synonymous with the use of long running computationally intensive simulations. This fuels the desire to harness the efficiency of surrogate-based methods in aerospace design optimization.
Alexander I.J. Forrester, Andy J. Keane, Keane, Andy J., Forrester, Alexander I.J.   +3 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Enhancing the Harmony Search Algorithm Performance on Constrained Numerical Optimization

IEEE Access, 2017
In this paper, an improved harmony search (ImHS) algorithm is presented. HS is a simple but efficient metaheuristic method explored in recent literature, that simulates the process of musical improvisation.
Edgar Alfredo Portilla-Flores, Alvaro Sanchez-Marquez, Leticia Flores-Pulido, Eduardo Vega-Alvarado, Maria Barbara Calva Yanez, Jorge Alexander Aponte-Rodriguez, Paola Andrea Nino-Suarez   +6 more
doaj   +1 more source

Preface of the “Symposium on Numerical Optimization and Applications” [PDF]

AIP Conference Proceedings, 2012
Numerical Optimization and Applications Symposium emphasizes modeling, theory and study of numerical algorithms for optimization. Optimization is an important tool in decision science and in the analysis of physical systems. Furthermore the Optimization plays central role in a tremendous variety of application in the natural sciences, in the sectors of
Pereira, Ana I., Costa, M. Fernanda P.
openaire   +3 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Hybridization of Grey Wolf Optimizer and Crow Search Algorithm Based on Dynamic Fuzzy Learning Strategy for Large-Scale Optimization

IEEE Access, 2020
A novel optimization algorithm named hybrid grey wolf optimizer with crow search algorithm (GWO-CSA) is developed in this paper for handling large-scale numerical optimization problems.
Rizk Masoud Rizk-Allah, Adam Slowik, Aboul Ella Hassanien   +2 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source