Results 131 to 140 of about 419,543 (296)
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
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Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
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Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti +10 more
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Mathematics OpenThe numerical range of a matrix is a compact convex set in the complex plane that contains the convex hull of the spectrum of the matrix. A key question is whether the origin belongs to the convex hull of the spectrum or the numerical range.
Cheng Guo, Shanhui Fan
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On the numerical range of an operator [PDF]
Proceedings of the Japan Academy, Series A, Mathematical Sciences, 1971 Furuta, Takayuki, Nakamoto, Ritsuo
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Numerical range of linear pencils
Linear Algebra and its Applications, 2000 AbstractConsider a linear pencil Aλ+B, where A and B are n×n complex matrices. The numerical range of Aλ+B is defined asW(Aλ+B)=λ∈C:x*(Aλ+B)x=0forsomenonzerox∈Cn.In this paper, we study the geometrical properties of W(Aλ+B), with emphasis to its boundary. An answer to the problem of the numerical approximation of W(Aλ+B), when one of the coefficients A
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Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
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