Results 51 to 60 of about 2,436,536 (336)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Magnetization Switching in Nanowires: Monte Carlo Study with Fast Fourier Transformation for Dipolar Fields [PDF]

, 2000
For the investigations of thermally activated magnetization reversal in systems of classical magnetic moments numerical methods are desirable. We present numerical studies which base on time quantified Monte Carlo methods where the long-range dipole ...
Acharyya, Aharoni, Aharoni, Berkov, Braun, Braun, Braun, Braun, Coffey, Coffey, D. Hinzke, Garcı́, Gonzáles, Hinzke, Hinzke, Hubert, Hucht, Lyberatos, Nakatani, Nowak, Nowak, Press, U. Nowak, Wernsdorfer, Wernsdorfer, Yuan, Zhang   +26 more
core   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Numerical studies of variable-range hopping in one-dimensional systems

, 2009
Hopping transport in a one-dimensional system is studied numerically. A fast algorithm is devised to find the lowest-resistance path at arbitrary electric field.
A. I. Larkin, A. O. Orlov, A. S. Rodin, B. I. Shklovskii, B. I. Shklovskii, B. I. Shklovskii, E. I. Levin, M. E. Raikh, M. E. Raikh, M. M. Fogler, N. G. van Kampen, T. Giamarchi   +11 more
core   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Improved numerical methods for infinite spin chains with long-range interactions

, 2013
We present several improvements of the infinite matrix product state (iMPS) algorithm for finding ground states of one-dimensional quantum systems with long-range interactions. As a main new ingredient we introduce the superposed multi-optimization (SMO)
J. Cardy, T. Giamarchi, V. Nebendahl, W. Arnoldi, W. Dür, Y. Saad   +5 more
core   +1 more source

An Efficient Numerical Model to Predict the Mechanical Response of a Railway Track in the Low-Frequency Range [PDF]

, 2022
Maryam El Moueddeb, François Louf, Pierre‐Alain Boucard, Franck Dadié, Gilles Saussine, Danilo Sorrentino   +5 more
openalex   +1 more source

Numerical shadows: Measures and densities on the numerical range

Linear Algebra and its Applications, 2011
For any operator $M$ acting on an $N$-dimensional Hilbert space $H_N$ we introduce its numerical shadow, which is a probability measure on the complex plane supported by the numerical range of $M$. The shadow of $M$ at point $z$ is defined as the probability that the inner product $(Mu,u)$ is equal to $z$, where $u$ stands for a random complex vector ...
Dunkl, Charles F., Gawron, Piotr, Holbrook, John A., Puchała, Zbigniew, Życzkowski, Karol   +4 more
openaire   +3 more sources

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Relaxation of spherical systems with long-range interactions: a numerical investigation

, 2011
The process of relaxation of a system of particles interacting with long-range forces is relevant to many areas of Physics. For obvious reasons, in Stellar Dynamics much attention has been paid to the case of 1/r^2 force law.
Bertin G., Bertin G., Binney J., Ciotti L., Hénon M., LUCA CIOTTI, PIERFRANCESCO DI CINTIO   +6 more
core   +1 more source