Results 71 to 80 of about 463,320 (265)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Some weighted operator geometric mean inequalities
پژوهشهای ریاضی, 2017 In this paper, using the extended Holder- -McCarthy inequality, several inequalities involving the α-weighted geometric mean ...
Alemeh Sheikhhosseini +2 more
doaj
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Computing the numerical range of Krein space operators
Open Mathematics, 2014 Consider the Hilbert space (H,〈• , •〉) equipped with the indefinite inner product[u,v]=v*J u,u,v∈ H, where J is an indefinite self-adjoint involution acting on H.
Bebiano Natalia +3 more
doaj +1 more source
Numerical Ranges of Antilinear Operators
Integral Equations and Operator TheoryAbstractWe study numerical ranges of antilinear operators on both Hilbert and Banach spaces. We prove that the numerical range of an antilinear operator on at least two-dimensional space is always a disc, and so a convex set. This improves existing results.
Damian Kołaczek, Vladimir Müller
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
On some numerical characteristics of operators
Arab Journal of Mathematical Sciences, 2015 We investigate some numerical characteristics of Toeplitz operators including the numerical range, maximal numerical range and maximal Berezin set. Further, we establish an inequality for the Berezin number of an arbitrary operator on the Hardy–Hilbert ...
M. Gürdal +3 more
doaj +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source