Results 101 to 110 of about 93,562 (275)
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Living Reviews in Relativity, 2004 The notion of conformal infinity has a long history within the research in Einstein's theory of gravity. Today, 'conformal infinity' is related to almost all other branches of research in general relativity, from quantisation procedures to abstract ...
Frauendiener Jörg
doaj
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Numerical Approaches to Spacetime Singularities
Living Reviews in Relativity, 1998 This review updates a previous review article. Numerical explorationof the properties of singularities could, in principle, yield detailed understanding of their nature in physically realistic cases.
Beverly K. Berger
doaj
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Axisymmetric Numerical Relativity
, 2006 This thesis is concerned with formulations of the Einstein equations in axisymmetric spacetimes which are suitable for numerical evolutions. We develop two evolution systems based on the (2+1)+1 formalism. The first is a (partially) constrained scheme with elliptic gauge conditions arising from maximal slicing and conformal flatness.
openaire +2 more sources
Numerical Relativity and Astrophysics
Annual Review of Astronomy and Astrophysics, 2014 Throughout the Universe many powerful events are driven by strong gravitational effects that require general relativity to fully describe them. These include compact binary mergers, black hole accretion, and stellar collapse, where velocities can approach the speed of light and extreme gravitational fields (ΦNewt/c2≃1) mediate the interactions.
Lehner, Luis, Pretorius, Frans
openaire +2 more sources
Living Reviews in Relativity, 2000 The notion of conformal infinity has a long history within the research in Einstein's theory of gravity. Today, ``conformal infinity'' is related with almost all other branches of research in general relativity, from quantisation procedures to abstract ...
Frauendiener Jörg
doaj
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source