Results 161 to 170 of about 225,512 (313)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A class of Petrov-Galerkin finite element methods for the numerical solution of the stationary convection-diffusion equation. [PDF]

, 1996
A class of Petrov-Galerkin finite element methods is proposed for the numerical solution of the n dimensional stationary convection-diffusion equation.
Perella, A.J., Perella, Andrew James
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Development of a symplectic and phase error reducing perturbation finite-difference advection scheme

, 2016
The aim of this work is to develop a new scheme for solving the pure advection equation. This scheme formulated within the perturbation finite-difference context not only conserves symplecticity but also preserves the numerical dispersion relation ...
高智, Yu CH, Sheu TWH, Sheu, TWH (reprint author), Natl Taiwan Univ, Dept Engn Sci & Ocean Engn, 1,Sec 4,Roosevelt Rd, Taipei 106, Taiwan.   +3 more
core   +1 more source

Hilbert schemes of hypersurfaces and numerical criterions.

MATHEMATICA SCANDINAVICA, 1985
The paper studies n-dimensional varieties in \({\mathbb{P}}^ N\) which are hypersurfaces in some linear subspace. These are called n-hypersurfaces. The first theorem in the paper states that if \(n>0\), then a subscheme of \({\mathbb{P}}^ N\) with the Hilbert polynomial of an n-hypersurface is indeed an n-hypersurface.
openaire   +3 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Numerical solution of the eXtended Pom-Pom model for viscoelastic free surface flows

, 2011
In this paper we present a finite difference method for solving two-dimensional viscoelastic unsteady free surface flows governed by the single equation version of the eXtended Pom-Pom (XPP) model. The momentum equations are solved by a projection method
Tome, Murilo F., C.M. Oishi, M.F. Tomé, OISHI, C. M., Oishi, C.M., J.A. Cuminato, F.P. Martins, Cuminato, J.A., Oishi, C. M. [UNESP], Cuminato, Jose, S. McKee, Tomé, M.F., Cuminato, J. A., Tome, M. F., Martins, F.P., Mckee, Sean, McKee, S., Martins, F. P. [UNESP], MARTINS, F. P.   +18 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dynamic contact of two Gao beams

Electronic Journal of Differential Equations, 2012
The dynamic contact of two nonlinear Gao beams that are connected with a joint is modeled, analyzed, and numerically simulated. Contact is modeled with either (i) the normal compliance condition, or (ii) the unilateral Signorini condition.
Jeongho Ahn, Kenneth L. Kuttler, Meir Shillor   +2 more
doaj