Results 111 to 120 of about 137,188 (265)

Layer resolving numerical scheme for singularly perturbed parabolic convection-diffusion problem with an interior layer. [PDF]

MethodsX, 2023
Kusi GR, Habte AH, Bullo TA.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A uniformly convergent numerical scheme for solving singularly perturbed differential equations with large spatial delay. [PDF]

SN Appl Sci, 2022
Ejere AH, Duressa GF, Woldaregay MM, Dinka TG.   +3 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Mathematical Analysis of Malware Spread in Digital Systems Using Atangana–Baleanu–Caputo Fractional Dynamics

Algorithms
This study explores the spread of malware within a digital framework by introducing a unique fractional-order model that employs the Atangana–Baleanu–Caputo (ABC) derivative.
Tharmalingam Gunasekar, Rajendran Swetha, Shanmugam Manikandan, Sally Almanasra, Suad AlRamouni   +4 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A numerical scheme for the ground state of rotating spin-1 Bose-Einstein condensates. [PDF]

Sci Rep, 2021
Sriburadet S, Shih YT, Jeng BW, Hsueh CH, Chien CS.   +4 more
europepmc   +1 more source

A Numerical Scheme for BSVIEs

, 2016
In this paper, we consider the Euler method for backward stochastic Volterra integral equations. First, we approximate the original equation by a family of backward stochastic equations (BSDEs, for short). Then we solve the BSDEs by the Euler method.
openaire   +2 more sources

Numerical schemes for the solution of the telegrapher equation

Numerical Algorithms
Abstract The present work deals with the numerical resolution of the telegrapher equation. We present various numerical explicit and implicit schemes for problems defined in one-dimensional domains. In this case, we consider, on one hand, Dirichlet boundary value conditions and in the other hand, the mixed ones.
Pierre Spitéri, Frédéric Messine
openaire   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source