Results 71 to 80 of about 4,654,918 (291)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Numerical simulation of multifluid flows with the particle finite element method [PDF]
, 2010 In this monograph we have focused on understanding the basic physical principles of multi-fluid flows and the difficulties that arise in their numerical simulation.
Oñate Ibáñez de Navarra, Eugenio +2 more
core +2 more sources
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Deterministic numerical solutions of the Boltzmann equation using the fast spectral method [PDF]
, 2013 The Boltzmann equation describes the dynamics of rarefied gas flows, but the multidimensional nature of its collision operator poses a real challenge for its numerical solution. In this paper, the fast spectral method [36], originally developed by Mouhot
Reese, Jason M. +6 more
core +3 more sources
Computations of the Shock Waves at Hypersonic Velocities Taken into Account the Chemical Reactions that Appear in the Air at High Temperatures [PDF]
INCAS Bulletin, 2015 The temperature in the nose region of a hypersonic vehicle can be extremely high, for example, reaching approximately 11 000 K at a Mach number of 36 (Apollo reentry).
Mihai Leonida NICULESCU +3 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
The completion of the mathematical model by parameter identification for simulating a turbofan engine [PDF]
INCAS Bulletin, 2015 The purpose of this paper is to set up a method to determine the missing engine design parameters (turbine inlet temperature T3T, airflow rate) which significantly influence the jet engines thrust.
Irina Carmen ANDREI +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Abstract Several of the numerical simulation exercises proposed in the following chapters require step-by-step raytracing through the optical elements concerned, for diverse reasons, depending on the problem. The raytracing code Zgoubi is used and provides the necessary tooling for this numerical solution of particle and spin motion ...
+5 more sources
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source