Results 71 to 80 of about 1,710,737 (289)
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Proper Orthogonal Decomposition Closure Models For Turbulent Flows: A Numerical Comparison
, 2011 This paper puts forth two new closure models for the proper orthogonal decomposition reduced-order modeling of structurally dominated turbulent flows: the dynamic subgrid-scale model and the variational multiscale model.
Ahuja +74 more
core +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Image Scale-Space Filtering Using Directional Local Variance Controlled Anisotropic Diffusion
Discrete Dynamics in Nature and Society, 2021 The purpose of this paper is to develop an effective edge indicator and propose an image scale-space filter based on anisotropic diffusion equation for image denoising.
Yong Chen, Taoshun He
doaj +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Symplectic Model Order Reduction with Non-Orthonormal Bases
Mathematical and Computational Applications, 2019 Parametric high-fidelity simulations are of interest for a wide range of applications. However, the restriction of computational resources renders such models to be inapplicable in a real-time context or in multi-query scenarios.
Patrick Buchfink +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
AbstractSeveral of the numerical simulation exercises proposed in the following chapters require step-by-step raytracing through the optical elements concerned, for diverse reasons, depending on the problem. The raytracing code Zgoubi is used and provides the necessary tooling for this numerical solution of particle and spin motion in electric and/or ...
+5 more sources
International Journal of Antennas and Propagation, 2016 Former works show that the accuracy of the second-kind integral equations can be improved dramatically by using the rotated Buffa-Christiansen (BC) functions as the testing functions, and sometimes their accuracy can be even better than the first-kind ...
Yue-Qian Wu +3 more
doaj +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source