Results 51 to 60 of about 4,654,918 (291)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Optimization of refueling docking trajectory for multi-UAV formation

Xibei Gongye Daxue Xuebao
Aiming at the optimization of autonomous docking trajectory of unmanned receiver in the in-flight refueling, a high-precision computational fluid dynamics method was used to calculate the dangerous area behind the refueling aircraft as the obstacle in ...
WANG Yuyan, ZHANG Wenhao, CHAI Yong, YUAN Zelan, LIANG Yihua   +4 more
doaj   +1 more source

A note on hyperbolic relaxation of the Navier-Stokes-Cahn-Hilliard system for incompressible two-phase flows [PDF]

ESAIM: Proceedings and Surveys
We consider the two-phase dynamics of two incompressible and immiscible fluids. As a mathematical model we rely on the Navier-Stokes-Cahn-Hilliard system that belongs to the class of diffuse-interface models.
Keim Jens, Konan Hasel-Cicek, Rohde Christian   +2 more
doaj   +1 more source

Towards the Numerical Simulation of Electrocardiograms

, 2007
We present preliminary results of the numerical simulation of electrocardiograms (ECG). We consider the bidomain equations to model the electrical activity of the heart and a Laplace equation for the torso. The ionic activity is modeled with a Mitchell-Schaeffer dynamics.
Boulakia, M, Fernández, M, Gerbeau, J, Zemzemi, N   +3 more
openaire   +2 more sources

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Numerical Simulation of a Turbulent Flow in a Channel with Surface Mounted Cubes [PDF]

, 1998
In this paper we report on a fourth-order, spectro-consistent simulation of a complex turbulent flow. A spatial discretization of a convection-diffusion equation is termed spectro-consistent if the spectral properties of the convective and diffusive ...
Veldman, A.E.P., Verstappen, R.W.C.P., R. W. C. P. Verstappen, Verstappen, R.W.C.P.,, Veldman, A.E.P.,, A. E. P. Veldman   +5 more
core   +1 more source

Effect of divergence on the compressible flow patterns in off-design planar nozzles [PDF]

FME Transactions
In the present work, the objective is to determine the Mach number and static pressure flow field behavior for off-design planar nozzle geometries with divergent angles of 1.21° (model A1) and 10.85° (model B1).
Tolentino San L., Mírez Jorge
doaj   +1 more source

Numerical Analysis of Fourier Finite Volume Element Method for Dirichlet Boundary Optimal Control Problems Governed by Elliptic PDEs on Complex Connected Domains

Mathematics, 2022
In this research, we investigate an optimal control problem governed by elliptic PDEs with Dirichlet boundary conditions on complex connected domains, which can be utilized to model the cooling process of concrete dam pouring.
Mengya Su, Liuqing Xie, Zhiyue Zhang
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source