Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Experimental Validation of a Robust [FO-PID]λ Controller
MathematicsFractional order controllers are more frequently encountered in industrial applications due to their robustness and the improved performance they offer to the system.
Nicoleta E. Badau +2 more
doaj +1 more source
Improving the computational accuracy of the dynamic electro-geometrical model using numerical solutions. [PDF]
Sci Rep, 2022 Adekitan AI.
europepmc +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Numerical Solutions of Variable Coefficient Higher-Order Partial Differential Equations Arising in Beam Models. [PDF]
Entropy (Basel), 2022 Ghafoor A +4 more
europepmc +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
A numerical method for the solution of plane crack problems in finite media
International Journal of Mathematics and Mathematical Sciences, 1980 A general method for the solution of plane isotropic elasticity crack problems inside a finite medium of arbitrary shape or an infinite medium with holes of arbitrary shape is presented.
P. S. Theocaris, N. Ioakimidis
doaj +1 more source
Publisher Correction: Improving the computational accuracy of the dynamic electro-geometrical model using numerical solutions. [PDF]
Sci Rep, 2022 Adekitan AI.
europepmc +1 more source
Application of the Front-Fixing Method to Numerical Modeling of Field Diffusion in Nonlinear Systems
, 2009 Application of a finite volume front-fixing method to a thermistor problem with strongly nonlinear material properties is discussed. Advantages and implementation problems of the method are highlighted.
Golosnoy, I.O., Sykulski, J.K.
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source