Results 121 to 130 of about 105,644 (294)

AlphaFold2‐Guided Cyclic Peptide Stabilizer Design to Target Protein–Protein Interactions

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The control and modulation of protein–protein interactions (PPIs) is of central importance for the majority of biological processes and most biomedical applications. Stabilization of PPIs, besides inhibition, is of growing pharmaceutical interest.
Niklas Halbwedl, Martin Zacharias
wiley   +1 more source

The Allium cepa Derived Compound Propyl Propane Thiosulfonate (PTSO) Improves Tumorigenesis Due to Its Immunomodulatory Effect: A Preclinical Study

Phytotherapy Research, EarlyView.
In vitro and in vivo effects of PTSO in colorectal cancer preclinical models, highlighting antiproliferative, pro‐apoptotic, barrier‐enhancing, antitumor, prebiotic and immunomodulatory properties. Created using BioRender. ABSTRACT Allium‐derived organosulfur compounds offer significant health benefits.
María Jesús Rodríguez‐Sojo, Laura Hidalgo‐García, Jose Alberto Molina‐Tijeras, Laura López‐Escanez, Luckman Gbati, Teresa Vezza, Patricia Diez‐Echave, Antonio Jesús Ruiz‐Malagón, Jorge García‐García, Federico García, Alberto Baños, Lidia Gil‐Martínez, Rocío López‐Posadas, Markus F. Neurath, Julio Gálvez, María Elena Rodríguez‐Cabezas, Alba Rodríguez‐Nogales   +16 more
wiley   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, EarlyView.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source

Sensory Biology of the Franciscana (Pontoporia blainvillei, Pontoporiidae, Cetartiodactyla): Ontogenetic Modifications of Vibrissae and Vibrissal Crypts

Integrative Zoology, EarlyView.
The transition of cetaceans from a terrestrial to an aquatic environment involved a crucial sensory adaptation to environments with limited visibility. Vibrissae, important mechanoreceptors, undergo an ontogenetic transformation in odontocetes. This research describes the histomorphology of vibrissae and crypts at different developmental stages ...
Cecilia Mariana Krmpotic, Cleopatra Mara Loza, Alejo Carlos Scarano, Pedro Fernando Andrés‐Laube, Francisco Acuña, Juan Pablo Loureiro, Carolina Natalia Zanuzzi, Nicolás Nahuel Castro, María Teresa Pombo, Lorenzo von Fersen, Claudio Gustavo Barbeito   +10 more
wiley   +1 more source

MorphSim: An R package for simulating discrete morphological data

Methods in Ecology and Evolution, EarlyView.
Abstract Morphological data are essential for reconstructing evolutionary histories, particularly for fossil taxa, as they represent the primary source of information for integrating extinct lineages into phylogenetic analyses. Despite this, tools for simulating realistic morphological datasets for fossil‐inclusive phylogenetic workflows remain limited.
Laura P. A. Mulvey, Tim Brandler, Alessio Capobianco, Rachel C. M. Warnock, Joëlle Barido‐Sottani   +4 more
wiley   +1 more source

Mapping Local and Regional Potentials for Inter-sectoral Technology Flows in Industrial Clusters – Empirical Results for Germany [PDF]

The paper explores the potential for inter-sectoral technology flows in industrial clusters in Germany. With the help of a product-embodied R&D flow matrix, calculated using data on input–output tables and sectoral R&D employment, we construct industrial
Hans-Ulrich Brautzsch, Matthias Brachert, Mirko Titze   +2 more
core  

Lady Anne Kerr: From the Rise of International Conference Interpreting to the Whitlam Dismissal

Australian Journal of Politics &History, EarlyView.
Before Anne Robson (née Taggart) became the second Lady Kerr upon marrying governor‐general John Kerr in 1975, she had an international career of some 30 years working as a French to English interpreter and consultant at over 30 national and international conferences and became the first Australian elected to the International Association of Conference
Alexis Bergantz
wiley   +1 more source

Rulers on the road: Itinerant rule in the Holy Roman Empire, AD 919–1519

American Journal of Political Science, EarlyView.
Abstract Itinerant rule, rule exercised through traveling, was a common yet insufficiently researched, premodern form of governance. Studying the determinants of ruler itineraries in the Holy Roman Empire, AD 919–1519, we argue that rulers' visits targeted “marginal” elites.
Carl Müller‐Crepon, Clara Neupert‐Wentz, Andrej Kokkonen, Jørgen Møller   +3 more
wiley   +1 more source

Hearing the Victim\u27s Voice: Analysis of Victims\u27 Advocate Participation in the Trial Proceeding of the International Criminal Court [PDF]

, 2005
Mekjian, Gerard J., Varughese, Mathew C.
core   +2 more sources

Frequency and Severity of Allergic Reactions to Non‐Mandatory Labelled Allergenic Foods—Data From Two Large European Cohorts

Allergy, EarlyView.
In two large European cohorts, 589 reactions to non‐mandatory labelled plant‐based foods were identified with sunflower seed, pine nut, pea and lentil as the most frequent triggers. Reaction severity was not different between mandatory and non‐mandatory labelled allergenic foods. Their frequency and rising trends (e.g., fenugreek, pumpkin seed) support
Sabine Dölle‐Bierke, Alejandro Gonzalo‐Fernández, Dominique Sabouraud‐Leclerc, Laura Barreales‐Tolosa, Barbara Ballmer‐Weber, Simona Belohlavkova, Maria B. Bilò, Ruta Dubakiene, Karin Hartmann, Monika Jedrzejczak‐Czechowicz, Thuy‐My Le, Lars Lange, Nikolaos G. Papadopoulos, Guillaume Pouessel, Isabel Reig, Athanasios Sinaniotis, E. N. Clare Mills, Margitta Worm, Montserrat Fernández‐Rivas   +18 more
wiley   +1 more source