Results 91 to 100 of about 651,670 (294)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2009 Student nurses in a transatlantic exchange program explored the role of registered nurses in five countries’ public health systems. The Ottawa Charter provided a framework for students to examine the nurse’s responsibilities in public health.
Chasse, F. +19 more
core +1 more source
Psychological Resilience and Associated Factors in Cancer Patients: A Cross‐Sectional Analysis
Cancer ReportsBackground Cancer remains one of the leading global health problems, with treatments that can compromise patients' quality of life. Aims This study aimed to determine the prevalence and characteristics of resilience in cancer patients and to analyze the ...
Marta Esteban Blanco +6 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Providing the family-nurse partnership programme through interpreters in England
, 2011 This study looks at the delivery of the Family-Nurse Partnership (FNP) in England with interpreters. This home-visiting programme for vulnerable, young first-time mothers is known in the USA as the Nurse-Family Partnership (NFP). FNP is manualised with a
Barnes, Jacqueline +5 more
core +1 more source
Stress among nursing undergraduate students of a Brazilian public university
Investigación y Educación en Enfermería, 2016 Objective. To determine the level of stress among students of an undergraduate course in nursing of a Brazilian public university. Methods. Cross-sectional study involving 111 students who responded to the 30 item questionnaire of Costa and Polak for ...
Verusca Soares de Souza +6 more
doaj
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
, 2014 IntroductionIdentifying safe approaches to nurse staffing in hospital wards is a key challenge for healthservice providers. The National Institute for Health and Care Excellence (NICE) has beenasked by the Department of Health and NHS England to develop ...
James, Liz +6 more
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source