Results 41 to 50 of about 729,302 (264)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Human Security and Existential Threats: A Governance Framework for Planet, Peace, People & Prosperity

Cadmus, 2023
A key priority for Human Security in the 21st Century is the prevention of existential threats to human civilisation to ensure the well-being of our future generations.
Joanna Nurse
doaj  

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Functional disability and morbidities among the elderly people, according to socio-demographic conditions and indicative of depression

Investigación y Educación en Enfermería, 2017
Objectives. To investigate the association of functional incapacity and the number of morbidities with sociodemographic, economic and health variables. Methods.
Bárbara Ferreira Agreli, Flavia Aparecida Dias, Pollyana Cristina dos Santos Ferreira, Nayara Cândida Gomes, Darlene Mara dos Santos Tavares   +4 more
doaj   +1 more source

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

Molecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo, Carlos M. Martínez‐Cáceres, Manuel Bernabé‐García, Vicente Munitiz, David Ruiz de Angulo, Pascual Parrilla, Ángeles Ortiz, Luisa F. Martínez de Haro, María L. Cayuela   +8 more
wiley   +1 more source

Strategies of care for adolescent users of crack undergoing treatment

Investigación y Educación en Enfermería, 2019
Objective. To analyze the care strategies of the adolescent crack user under treatment.  Methods. Study of qualitative approach of descriptive type. The participants were 20 professionals from the Centro de Atenção Psicossocial Álcool e Drogas (Center ...
Juliane Portella Ribeiro, Giovana Calcagno Gomes, Marina Soares Mota, Elitiele Ortiz Santos, Adriane Domingues Eslabão   +4 more
doaj   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Meaning of parenting as a teenager

Investigación y Educación en Enfermería, 2017
Objective. Describe the meaning of parenting as a teenager. Methods. Study of the qualitative approach with phenomenological approach in the fourth village of San Cristobal (Bogotá, Colombia).
Carolina Antolinez Figueroa, Carlos Julio Saavedra Cantor, Ana Helena Puerto Guerrero, Carol Margeth Calderón Romero   +3 more
doaj   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Dentality areal features and phonological change in northeastern Bantu

Studies in African Linguistics, 1985
A minority of the world's languages appear to have a series of dental (as opposed to alveolar) obstruents. Proto-Bantu does not have such a series, nor do most East African Bantu languages.
Derek Nurse
doaj   +3 more sources