Results 51 to 60 of about 477,700 (249)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Dentality areal features and phonological change in northeastern Bantu

Studies in African Linguistics, 1985
A minority of the world's languages appear to have a series of dental (as opposed to alveolar) obstruents. Proto-Bantu does not have such a series, nor do most East African Bantu languages.
Derek Nurse
doaj   +3 more sources

Auricular Acupoint Selection Patterns for Knee Osteoarthritis Pain Relief: A Systematic Review and Data Mining Analysis

Journal of Pain Research
Yawen Li,1,2 Xinyue Zhang,2 Mengnan Liu,1,2 Yin Wang,2 Zhongming Shen,1 Yawei Shan1,2 1Department of Nursing, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 2School of Nursing ...
Li Y, Zhang X, Liu M, Wang Y, Shen Z, Shan Y   +5 more
doaj  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Severity-Stratified Pulmonary Rehabilitation Modulates Diaphragm Function and Oxidative Stress in Hospitalized AECOPD Patients: A Randomized Controlled Trial

International Journal of COPD
Hui Zeng,1,2,* Hongmin Ran,2,* Yan Wang,1 Yue Chen,2 Lijuan Zhang,1 Dehua Zhao,1 Dandan Fu,1 Nana Yang,3 Changxiu Li,3 Lina Ma,2 Jimei Luo,1,2 Qiuhang Hu,1,2 Lulu Huang1,2 1The Second Affiliated Hospital of Zunyi Medical University, Zunyi,
Zeng H, Ran H, Wang Y, Chen Y, Zhang L, Zhao D, Fu D, Yang N, Li C, Ma L, Luo J, Hu Q, Huang L   +12 more
doaj  

Preliminary Effects of Low Intensity Exercise on Quality of Sleep, Activity of Daily Living, and Physiological Indicators of Kidney Function in Hemodialysis Patients

Nursing and Healthcare Science
Purpose: This preliminary study explored the effects of a 6-month low intensity exercise program on sleep, activity of daily living, physiological indicators in hemodialysis patients. Methods: A non-equivalent control group pre-post test design was used.
Kwi Kyung Kim, Jung Hwa Lee, Young Je Jo, Jeong Mi Lee, Ji Min Bang, Hae In Jeong, Kyung Hee Lim   +6 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Establishment and Verification of Risk Prediction Model for Adverse Outcomes After Hip Arthroplasty in Elderly Patients

Therapeutics and Clinical Risk Management
Jie Ding,1 Guoli Sun,2 Yifei Ren,1 Jiajia Xu,1 Qingqing Hu,1 Jun Luo,1 Zhaowen Wu,1 Ting Chu1 1School of Nursing, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310053, People’s Republic of China; 2Department of Orthopaedics, The ...
Ding J, Sun G, Ren Y, Xu J, Hu Q, Luo J, Wu Z, Chu T   +7 more
doaj  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source