Results 231 to 240 of about 1,546,300 (344)

Therapeutic Gene Editing: DNA Repair Pathways, Emerging Editors, and Clinical Progress

iNew Medicine, EarlyView.
ABSTRACT The field of gene editing has evolved rapidly over the past decade, progressing from programmable zinc‐finger nucleases (ZFNs) and transcription activator‐like effector nucleases (TALENs) to the widespread adoption of CRISPR‐Cas systems. First‐generation editors catalyzed genome engineering by introducing targeted double‐strand breaks (DSBs ...
Li‐Kuang Tsai, Youcai Xiong, Dongqi Liu, Dongshan Yang, Jifeng Zhang, Jie Xu, Renzhi Han, Y. Eugene Chen   +7 more
wiley   +1 more source

How do clinicians navigate end-of-life care with NIV/CPAP? A thematic analysis study. [PDF]

BMJ Open
Wenzel D, Bleazard L, Wilson E, Creese J, Faull C.   +4 more
europepmc   +1 more source

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

UpToDate®. [PDF]

Nurse Pract
europepmc   +1 more source

Group Agency and Egalitarian Corporate Structure: The Epistemic, Incentive, and Control Dimensions

Journal of Applied Philosophy, EarlyView.
ABSTRACT What constitutes a good corporate agent? The article answers this question by critically applying List and Pettit's theory of group agency, which emphasizes three crucial dimensions of organizational design: epistemic quality, incentive compatibility, and control.
Chi Kwok, Chris Man‐Kong Li
wiley   +1 more source

Waiting room and hallway care for older adults: a qualitative study with emergency nurses and technicians. [PDF]

BMC Geriatr
Nessen SJ, Friedman AB, Bhananker AR, Muir KJ, Chary AN.   +4 more
europepmc   +1 more source

Fast Mid‐Infrared Spectral Probe Decisions Match H&E Stain Results for Keratinocytic Carcinoma

Journal of Biophotonics, EarlyView.
A handheld and fast mid‐infrared fiber‐optic spectral probe is touched to tissue recording a mid‐infrared spectrum that can distinguish keratinocytic cancer from normal skin. ABSTRACT We designed a handheld and fast mid‐infrared fiber‐optic spectral probe using a quantum cascade laser (QCL) and a reduced range of wavelengths, to see if keratinocytic ...
Rebecca C. Bradley, Maria G. Vazquez de Vasquez, Charles L. Hitchcock, Angela S. Casey, James V. Coe, Ronald Siegle   +5 more
wiley   +1 more source

A Shared Vision for Tracheostomy Care: How the ICN's Updated Framework Strengthens Collaboration. [PDF]

Tracheostomy
Pandian V, Brenner MJ.
europepmc   +1 more source

Psychometric Analysis of Scores on a Mexican Dialect Spanish Version of the PHQ‐9 With Mexican Earthquake Survivors

Journal of Counseling &Development, EarlyView.
ABSTRACT This study explored the psychometric characteristics of the PHQ‐9 scores in a sample of 289 Spanish‐speaking participants who endured the 2017 Mw7.1 earthquake, which impacted the Mexican states of Puebla and Morelos, as well as the Greater Mexico City area.
Khalid Stetkevych, Bradley T. Erford, Martin F. Sherman, Laura Shannonhouse   +3 more
wiley   +1 more source