Results 51 to 60 of about 1,546,300 (344)

What do primary care clinicians know about the management and control of Tuberculosis?

South African Family Practice, 2000
Objectives: To investigate primary care clinicians' knowledge of tuberculosis (TB) management and control. Methods: A cross-sectional survey of primary care clinicians in public service, attending the TB symposium organised for the 1999 World TB Day in ...
E. Balt, D.N. Durrheim, G.A. Ogunbanjo
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Evaluation of the diagnostic accuracy and cost of different methods for the assessment of severe  anaemia in hospitalised children in Eastern Uganda [version 1; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2018
Background: Severe anaemia in children requiring hospital admission is a major public health problem in malaria-endemic Africa. Affordable methods for the assessment of haemoglobin have not been validated against gold standard measures for identifying ...
Peter Olupot-Olupot, Natalie Prevatt, Charles Engoru, Julius Nteziyaremye, Denis Amorut, Martin Chebet, Tonny Senyondo, Paul Ongodia, Carolyne M. Ndila, Thomas N. Williams, Kathryn Maitland   +10 more
doaj   +1 more source

Establishment and implementation of a nurse-led interdisciplinary management strategy for central line maintenance: A single-center experience

International Journal of Nursing Sciences, 2023
Objectives: This study aimed to establish and implement an interdisciplinary management strategy led by senior nurses via a vascular access specialist team (VAST) at a teaching hospital.
Yuxin Yin, Changhua Tang, Lijie Zhang, Di Wu, Qing Sun   +4 more
doaj   +1 more source

Cystic Fibrosis Foundation and European Cystic Fibrosis Society Survey of cystic fibrosis mental health care delivery [PDF]

, 2015
Background: Psychological morbidity in individuals with cystic fibrosis (CF) and their caregivers is common. The Cystic Fibrosis Foundation (CFF) and European Cystic Fibrosis Society (ECFS) Guidelines Committee on Mental Health sought the views of CF ...
A.L. Quittner, A.M. Georgiopoulos, B.A. Smith, B.C. Marshall, Boyle, Braun, Clarke, DiMatteo, Fidika, Foy, Foy, Godfrey, Havermans, Health Disorders, J. Abbott, J.S. Elborn, K.A. Sabadosa, L. Goldbeck, Lewiston, Manfreda, Mitchell, Monkey, Moussavi, National Collaborating Centre For Mental Health (UK), National Collaborating Centre for Mental Health (UK), Nulty, Quittner, Riekert, Sawicki, Shih, Smith, Snell, Stern, West   +33 more
core   +1 more source

Physician and nurse well-being, patient safety and recommendations for interventions: cross-sectional survey in hospitals in six European countries

BMJ Open
Objectives To determine the well-being of physicians and nurses in hospital practice in Europe, and to identify interventions that hold promise for reducing adverse clinician outcomes and improving patient safety.
L. Aiken, W. Sermeus, M. Mckee, K. Lasater, D. Sloane, Colleen A. Pogue, Dorothea Kohnen, Simon Dello, Claudia B Maier, Jonathan Drennan, Mathew McHugh   +10 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Nurses’ Attitudes, Environmental Perceptions and Involvement in Research: A Multisite Study

Nursing Reports
Background: Although evidence-based practice is widely promoted in nursing, direct care nurses remain underrepresented in research activities. This study aimed to assess nurses’ attitudes toward research, their perceptions of the organizational research ...
Amanda J. Hessels, Ulanda Marcus-Aiyeku, Mani Paliwal, Carrie Ann Catanzaro, Kimberly Dimino, Jessica Crowley, Jessica Miszlay, Maria Manzella, Kimkyla Kritch, Rachel Kilpatrick, Kim Kranz, Serpouhi S. Vartivarian, Barbara McGoey   +12 more
doaj   +1 more source

Integration of extreme risk protection orders into the clinical workflow: Qualitative comparison of clinician perspectives.

PLoS ONE, 2023
Extreme risk protection orders (ERPO) seek to temporarily reduce access to firearms for individuals at imminent risk of harming themselves and/or others.
Kelsey M Conrick, Sarah F Porter, Emma Gause, Laura Prater, Ali Rowhani-Rahbar, Frederick P Rivara, Megan Moore   +6 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source