Results 181 to 190 of about 700,451 (244)

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan   +29 more
wiley   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

open access: yesAdvanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li   +15 more
wiley   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

open access: yesAdvanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su   +4 more
wiley   +1 more source

Nurse-Nurse Manager Conflict

The Health Care Manager, 2007
This study was conducted to determine the conflict management styles used by nurse managers when in conflict with nurses and to ascertain the differences between sociodemographic characteristics and the style used. The study was conducted on 71 nurse managers working in 3 different hospitals in Antalya (Turkey).
Filiz, Kantek, Ilkay, Kavla
openaire   +2 more sources

Nurse Manager Engagement

Nursing Administration Quarterly, 2013
To describe what nurse manager engagement means to nurse managers and staff nurses by incorporating an organizational dashboard to document engagement outcomes.Retaining engaged nurse managers is crucial for individual performance and organizational outcomes.
Linda R, Gray, Maria R, Shirey
openaire   +2 more sources

Management of Nursing Intensity

Nursing Clinics of North America, 1988
The Yale Nursing Intensity Project explored the use of patient classification, done primarily for staffing, as a measurement of nursing resources. Cross-hospital comparisons showed considerable interesting variation, yet to be explained, in minutes of care but there was considerable consistency in the relative nursing intensity of DRGs.
J D, Thompson, D, Diers
openaire   +2 more sources

Nurse Manager Orientation

AACN Advanced Critical Care, 2009
On the basis of the principles of management and leadership, our organization has worked over the years to formalize the orientation program for new nurse managers. This program meets the needs of new nurse managers and responds to today’s complex health care system needs. This article describes the components of a nurse manager orientation program for
Anne, Hawkins   +2 more
openaire   +2 more sources

Management training for nurses

Nursing Standard, 1991
Pauline Werhun and her colleagues describe an innovative approach to nurse management training in their health authority. The course they devised, which lasts a total of 18 months, received such a positive response from senior and charge nurses that there is now a waiting list for entry.
P, Werhun   +3 more
openaire   +2 more sources

Self-Management for Nurses

JONA: The Journal of Nursing Administration, 1992
Nurses at a 119-bed hospital in the southwestern United States successfully managed themselves for 5 years without head nurses. The authors describe the context for self-management, the initiation of the self-managed model, and the role and tasks of the self-managed nurse.
M, Jannotta, T, Maldonado
openaire   +2 more sources

The conflict management style of staff nurses and nurse managers

Journal of Advanced Nursing, 1991
Conflict is recognized as being a common occurrence in both everyday personal and professional nursing life, and it is now generally agreed that conflict can be both problematic and potentially beneficial to both individuals and organizations There is a large amount of anecdotal and narrative literature about the nature and sources of conflict which ...
openaire   +2 more sources

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