Results 41 to 50 of about 99,253 (306)

Effectiveness of a Structured Self-Management Intervention to Improve Quality of Life in Individuals With Chronic Obstructive Pulmonary Disease (AMPOC Study)

Open Respiratory Archives
Introduction: This study aimed to compare the effectiveness of a structured self-management program in patients with moderate–severe COPD followed up for 12 months, in improving quality of life, dyspnea, inhaler adherence, anxiety, and depression ...
Maite López Luque, Marta Chuecos Molina, Guadalupe Ortega Cuelva, M. Jesús Vázquez López, Francisco Orfila Pernas, Nina Granel Giménez, Esther Ruiz Rodríguez, M. Ángeles Santos Santos, Adrià Almazor Sirvent, Antonio Vallejo Domingo, Toni López Ruiz, Purificación Jordana Ferrando   +11 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The nursing contribution to chronic disease management: a whole systems approach: Report for the National Institute for Health Research Service Delivery and Organisation programme [PDF]

, 2010
Background Transforming the delivery of care for people with Long Term Conditions (LTCs) requires understanding about how health care policies in England and historical patterns of service delivery have led to different models of chronic disease ...
Kendall, Sally, McNeilly, Elaine, Wilson, Patricia M., Bunn, Frances, Brooks, Fiona, Procter, Susan, Gage, Heather   +6 more
core  

Supportive care for patients with oesophageal and other upper gastrointestinal cancers: The role of a specialist nurse in the team

, 2006
Summary The care pathway of patients with upper gastrointestinal cancers is complex. We retrospectively evaluated the patients’ opinions of support and supportive care given by a specialist nurse who led the care of such patients.
Lagergren, Jesper, Viklund, Pernilla, Wengström, Yvonne,, Lagergren, Jesper,, Viklund, Pernilla,, Wengstrom, Yvonne   +5 more
core   +1 more source

A New Primary Care Model Based on Population Needs: A Nationwide Cross-Sectional Study

Nursing Reports
Background/Objectives: The role of the primary health care nurse has evolved since the Spanish Ministry of Health officially established the professional profile of the nurse specialist in Primary Health Care in 2005.
Silvia Domínguez Fernández, Pedro García Martínez, María Isabel Mármol-López, Esther Nieto García, María Begoña Sánchez Gómez, Mª Guadalupe Fontán Vinagre, Diego Ayuso-Murillo, Susana Montenegro Méndez, Francisco Javier Pérez-Rivas   +8 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Prescribing and the epilepsy specialist nurse

, 2003
Increasingly, the epilepsy nurse specialist has become an integral part of the specialist epilepsy team. Nurse specialists, who practice at an advanced level, frequently advise patients on diagnosis and antiepileptic drug changes.
HOSKING, P
core   +1 more source