Results 91 to 100 of about 1,108,939 (244)

Unmet job expectations and transition challenges of newly qualified nurses in Northern Ghana

Asian Journal of Medical Sciences
Background: The transition from nursing student to qualified staff is often stressful, particularly in resource-limited settings. In Northern Ghana, newly qualified nurses (NQNs) face unique challenges that may affect job expectations and satisfaction.
Abdul-Malik Abdulai , Samson Alhassan , Mohammed Iddrisu , Samuel Neetumah Sei , Safura Seidu , Mina Sapio , Iddrisu Abdulai , Abdul-Samed Mohammed   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Planting Seeds of Innovation: A Quality Improvement Project to Advance Nursing Innovation

Interdisciplinary Journal of Partnership Studies, 2023
Background: Emerging needs of the 21st century, such as workforce shortages, increasing supply costs, and rising complexity related to chronic disease management, equitable care, and declining health outcomes have made it imperative for the health-care ...
Oriana Beaudet
doaj  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Outcomes of Simulation-Based Education on Prelicensure Nursing Students’ Preparedness in Identifying a Victim of Human Trafficking

Social Sciences
Background: Individuals who are victimized and exploited by the heinous crimes of human trafficking (HT) access healthcare during their exploitation, yet gaps in education on HT content exist in prelicensure nursing programs.
Debra McWilliams, Geraldine Cornell, Francine Bono-Neri   +2 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Correlation between Thinking Styles with Clinical Decision Making among Nurses Working in Educational Hospitals Affiliated to Tabriz University of Medical Sciences

Preventive Care in Nursing and Midwifery Journal, 2014
Background and Objectives: Considering the importance of thinking styles in individualschr('39') decision making, this study was conducted to investigate the correlation between thinking styles with clinical decision making among nurses working in ...
Elmira Hassanpour, Nadereh Naderi ravesh, Zahra Safavi Bayat, Malihe Nasiri, Kianoush Niroumand Zandi   +4 more
doaj  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source