Results 81 to 90 of about 912,704 (299)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The work of health visitors and school nurses with children with psychological and behavioural problems [PDF]

, 2008
<b>Aim</b>. This paper is a report of a study to describe the workload of health visitors and school nurses in relation to children and young people with psychological, emotional or behavioural problems, and to identify perceived challenges ...
Wilson, Paul, Graham Bryce, Barbour, R., Bryce, Graham, Philip Wilson, Connelly, G., Phin, L., Furnivall, Judy, Barbour, Rose, Judy Furnivall, Phin, Louise, Anna Stallard, Stallard, Anna, Stallard, A., Furnivall, J., Connelly, Graham, Bryce, G., Barbour, Rosaline S., Rosaline S. Barbour, Wilson, Philip, Louise Phin, Graham Connelly, Barbour, Rosaline   +22 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A comparative study of the knowledge and practices related to menstrual hygiene among adolescent girls in urban and rural areas of Sindh, Pakistan: A cross-sectional study

Women's Health
Background: Menstrual hygiene management plays a significant role in the achievement of sustainable development goals, including good health and well-being, quality education, gender equality, women’s empowerment, and sanitation.
Amina Aziz, Salma Memon, Farhana Aziz, Farzana Memon, Bakhtawar M Hanif Khowaja, Shehla Naeem Zafar   +5 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Response to “An overview of health workforce education and accreditation in Africa: implications for scaling-up capacity and quality”

Human Resources for Health, 2023
Alex Berland, Helen Ewing, Kathleen Capone, Erica Frank, Miriam Chickering   +4 more
doaj   +1 more source

A Pilot Study to Create a Culture of Innovation and Quality: Focus on a Nursing Association, Credentialing Center, and Foundation

Nursing Reports
Background/Objectives: In today’s rapidly evolving healthcare landscape, fostering a culture of innovation and continuous improvement is essential—especially within a nursing association that leads individual and organizational credentialing.
Marcela Cámpoli, Tanya Mulvey, Olivia Lemberger, Hannah Person, Kasey Bellegarde-Armstrong, Oriana Beaudet   +5 more
doaj   +1 more source

Planting Seeds of Innovation: A Quality Improvement Project to Advance Nursing Innovation

Interdisciplinary Journal of Partnership Studies, 2023
Background: Emerging needs of the 21st century, such as workforce shortages, increasing supply costs, and rising complexity related to chronic disease management, equitable care, and declining health outcomes have made it imperative for the health-care ...
Oriana Beaudet
doaj