Results 111 to 120 of about 2,643,813 (383)

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

Molecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo, Carlos M. Martínez‐Cáceres, Manuel Bernabé‐García, Vicente Munitiz, David Ruiz de Angulo, Pascual Parrilla, Ángeles Ortiz, Luisa F. Martínez de Haro, María L. Cayuela   +8 more
wiley   +1 more source

A Pilot Study to Create a Culture of Innovation and Quality: Focus on a Nursing Association, Credentialing Center, and Foundation

Nursing Reports
Background/Objectives: In today’s rapidly evolving healthcare landscape, fostering a culture of innovation and continuous improvement is essential—especially within a nursing association that leads individual and organizational credentialing.
Marcela Cámpoli, Tanya Mulvey, Olivia Lemberger, Hannah Person, Kasey Bellegarde-Armstrong, Oriana Beaudet   +5 more
doaj   +1 more source

Planting Seeds of Innovation: A Quality Improvement Project to Advance Nursing Innovation

Interdisciplinary Journal of Partnership Studies, 2023
Background: Emerging needs of the 21st century, such as workforce shortages, increasing supply costs, and rising complexity related to chronic disease management, equitable care, and declining health outcomes have made it imperative for the health-care ...
Oriana Beaudet
doaj  

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Factors determining the style of adaptation to the disease in patients treated oncologically

Journal of Education, Health and Sport, 2017
Introduction. Cancer diseases still have the strongest impact on the human psyche, leading to the overwhelming life crisis. Each person, depending on personality traits and well-developed defense mechanisms, reacts individually to the diagnosis of the ...
Ewa Smoleń, Magdalena Słysz, Magdalena Jarema, Karolina Hombek, Krzysztof Kalita   +4 more
doaj   +3 more sources

Staff Nurse Ratings of Implementation Self-Efficacy for EBP (ISE4EBP) and Organizational EBP Readiness [PDF]

, 2020
There is limited research about nurses' confidence in implementing evidence into clinical practice. The purpose of this study was to further test, refine and strengthen the Implementation Self-Efficacy for EBP (ISE4EBP) scale and gain knowledge about ...
Sobieski, Tessa
core  

Secondary traumatic stress in the emergency department [PDF]

, 2016
Aim: To investigate the prevalence of secondary traumatic stress among Emergency nurses in the West of Scotland and explore their experiences of this. Background: Unexpected death, trauma and violence are regular occurrences that contribute to the ...
Joy, Jane P., Morrison, Lindy E.
core   +3 more sources

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Outcomes of Simulation-Based Education on Prelicensure Nursing Students’ Preparedness in Identifying a Victim of Human Trafficking

Social Sciences
Background: Individuals who are victimized and exploited by the heinous crimes of human trafficking (HT) access healthcare during their exploitation, yet gaps in education on HT content exist in prelicensure nursing programs.
Debra McWilliams, Geraldine Cornell, Francine Bono-Neri   +2 more
doaj   +1 more source