Results 71 to 80 of about 373,136 (294)

Phospholipid Remodeling and Tri‐Layer Membrane Reconstruction Mediate Cognitive Effects of Humanized Milk Fat Globules in Neonatal Rats

open access: yesAdvanced Science, EarlyView.
Humanized milk fat globules (MFG) mimic the native composition and structure of human milk, achieved through remodeling of milk fat globule membrane phospholipid composition and reconstruction of the tri‐layer membrane structure. These humanized MFG exhibit improved structural stability and digestibility, and enhance neurodevelopment in formula‐fed rat
Shaolei Wang   +8 more
wiley   +1 more source

Development of Age‐ and Sex‐Specific Metabolomics‐Based Biological Ageing Clocks for 10‐Year Mortality Prediction

open access: yesAdvanced Science, EarlyView.
Metabolomics‐based ageing clocks developed using blood biomarkers from over 215 000 European adults, improved the prediction of 10‐year all‐cause mortality compared to traditional models. Biological age acceleration is associated with higher mortality risk, as each additional year of metabolic age corresponded to at least 8% increased risk. These tools
Lei Peng   +4 more
wiley   +1 more source

Ubc9‐Mediated SUMOylation of RPL3, an Unappreciated Mechanism against Hepatocyte Senescence by Repressing the DHX9‐p16 Axis

open access: yesAdvanced Science, EarlyView.
Liver aging is characterized by a decline in the expression of the SUMO‐conjugating enzyme Ubc9, resulting in reduced SUMOylation levels in hepatocytes, particularly in the case of ribosomal protein RPL3. Disruption of RPL3 SUMOylation increases its nuclear translocation. Interestingly, ribosome‐free RPL3 facilitates the recruitment of helicase DHX9 to
Hao Xie   +22 more
wiley   +1 more source

Educational challenges ahead of nursing from the perspective of faculty members of Mashhad University of Medical Sciences

open access: yesJournal of Advances in Medical Education and Professionalism, 2013
Introduction: Development of nursing profession is faced with new challenges. Role of education is important for advancement of nursing. Faculty members are experienced in education, and they are authentic sources for determining of the educational ...
ABBAS HEYDARI   +5 more
doaj  

Synergistic Anti‐Cancer Therapy Through Ultrasound‐Induced Piezocatalytic Therapy and Tumor Treatment Fields

open access: yesAdvanced Science, EarlyView.
A novel, wearable anti‐cancer platform synergistically combines tumor treating fields (TTFs) and piezocatalytic therapy (PCT) via ultrasound‐activated, lead‐free piezocomposites. This strategy efficiently suppresses tumor growth, modulates the immune microenvironment, and demonstrates strong therapeutic synergy in both mouse model of subcutaneous tumor
Jing Jin   +9 more
wiley   +1 more source

Erucic Acid, Derived by Lactobacillus Crispatus, Induces Ferroptosis in Cervical Cancer Organoids Through the PPAR‐δ Signaling Pathway

open access: yesAdvanced Science, EarlyView.
Utilizing PDO, cell lines and cervical cancer xenograft (CDX) models, the study demonstrate both in vitro and in vivo that the metabolite of L. crispatus, erucic acid, can modulate the proliferation, migration and invasion of cervical cancer by activating the PPAR‐δ pathway.
Qianwei Zhen   +8 more
wiley   +1 more source

Comparing nursing instructors and fourth-year nursing students’ perspectives on clinical education problems

open access: yesفصلنامه پرستاری،مامایی و پیراپزشکی, 2015
Background and Aim: Clinical education is the heart of nursing education. It is a complex process which is affected by different factors. Identifying the problems of clinical education is the first step to resolving them.
Mohammad Zahed Rokhzadi, Kambiz Zehni
doaj  

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