Results 91 to 100 of about 189,673 (176)

A Systematic Review of Substance Misuse Treatment Processes and Outcomes as Implemented in Prisons for Men in the UK

Criminal Behaviour and Mental Health, EarlyView.
ABSTRACT Background With a rising prison population, a substantial portion of whom are identified as substance misusers, it is important to understand the availability of treatment pathways, their successes and areas for improvement. Given the likely importance of national factors in criminal justice and substance use service provision, we chose to ...
Kim Barnett, Noor Butt, Rosie Allen, Pauline Goodlad, Anne Krayer, Adam O'Neill, Peter Huxley, Catherine Robinson, Emily Peckham, Rob Poole   +9 more
wiley   +1 more source

Phenobarbital Bioequivalence in Chinese Population: Considering the Role of Food on Pharmacokinetics

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Epilepsy is one of the most severe neurological disorders in the world, which might seriously endanger the lives of patients. Phenobarbital is an important medicine clinically used for the treatment of epilepsy, and it is irreplaceable in the treatment of generalized tonic–clonic seizures, focal seizures, status epilepticus, and pediatric ...
Wang Xinman, Liu Yuan, Sun Ying, Wang Yiyun   +3 more
wiley   +1 more source

Results of the ACCOuNT Trial: A Multi‐Institutional Prospective Pharmacogenomics Implementation Trial for African American Inpatients

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacogenomics implementation efforts have increased over the last decade, but no published prospective pharmacogenomics trials have formally evaluated utility in underrepresented populations. We present final results from the ACCOuNT trial, a multi‐institutional prospective study [NCT03225820] in which African American inpatients were genotyped and ...
Zhong Huang, Kevin J. O'Leary, Edith A. Nutescu, Matthew Jack, Thomas Chen, Gregory W. Ruhnke, James C. Lee, David George, Larry K. House, Randall Knoebel, Luke V. Rasmussen, Seth Hartman, Anish Choksi, Kiang‐Teck J. Yeo, Minoli A. Perera, Mark J. Ratain, David O. Meltzer, Peter H. O'Donnell   +17 more
wiley   +1 more source

Clinical Trials With Pragmatic Elements: A Review of Use Cases and Real‐World Data Utilization

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical trials with pragmatic elements can capture diverse patient populations, enable efficient follow‐up, and reflect routine clinical practices; yet there is limited understanding of their design features, characteristics, and use of real‐world data (RWD). Based on a targeted search of PubMed/EMBASE (Jan‐2016 to Jul‐2024), a review was conducted to
Le Su, Lei Chen, Seema Betigeri, Nancy Dreyer, Helga Gardarsdottir, Rachele Hendricks‐Sturrup, Mehmet Burcu   +6 more
wiley   +1 more source

The Supply of Investigational Medicinal Product and Management of Study Materials for Decentralized Participants—Insights from the Trials@Home RADIAL Proof‐of‐Concept Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Decentralized clinical trials (DCTs), which move trial activities to participants' homes or direct surroundings, offer potential advantages over conventional site‐based trials through reduced participant burden and improved accessibility. The direct‐to‐participant (DtP) delivery of investigational medicinal products (IMPs) and other study materials and
Megan Heath, Amos J. de Jong, Shaun Magorrian‐Spence, Chao Jin, Danny R. van Weelij, Lucas Pagnier, Yvonne van Rijswick, Volker Haufe, Bart Lagerwaard, Mira G. P. Zuidgeest, on behalf of the Trials@Home consortium   +10 more
wiley   +1 more source

Exploring Interactive Change Processes in Multifamily Therapy for Adolescents With Anorexia Nervosa

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Multifamily therapy (MFT) is a unique treatment approach that is growing in popularity for adolescents with anorexia nervosa (AN) and their families. MFT aims to create change through experiential and activity‐based content and purposeful use of group processes.
Clare Levenspiel, Lisa Dawson, Julian Baudinet, Deborah Mitchison, Andrew Wallis   +4 more
wiley   +1 more source

Acolhimento em um serviço de emergência: percepção dos usuários

Revista Brasileira de Enfermagem
Objetivou-se compreender como os usuários de um serviço de emergência percebiam a atuação da enfermagem na realização do acolhimento. Foram realizadas entrevistas com 382 usuários do serviço, de outubro de 2008 a março de 2009.
Maria Vilani Cavalcante Guedes, Ana Ciléia Pinto Teixeira Henriques, Morgama Mara Nogueira Lima   +2 more
doaj  

The difficult discussion on the deactivation of implantable cardioverter devices at the end of life: a systematic review

ESC Heart Failure, Volume 12, Issue 2, Page 733-760, April 2025.
Abstract Implantable cardioverter defibrillators (ICDs) reliably prevent death due to life‐threatening arrhythmias; this may become less relevant in people with more severe heart failure who are reaching the end of life (EOL). This review aimed to explore the ICD deactivation process and identify ethical issues, especially around the initiation of ...
Siobhan C. Murray, Claire McNamara, Anna V. Chatzi   +2 more
wiley   +1 more source

Digital implementation strategy to increase SGLT2 inhibitor uptake in heart failure: Study design of EMAIL‐HF

ESC Heart Failure, EarlyView.
Abstract Aims The EMAIL‐HF trial aims to evaluate whether a digital guideline implementation strategy can increase and accelerate initiation of sodium‐glucose co‐transporter 2 (SGLT2) inhibitors in patients with heart failure (HF). Methods and results EMAIL‐HF is a pragmatic, registry‐based, randomized controlled trial including patients with a ...
Mariam Elmegaard, Lars Køber, Mads Kristian Ersbøll, Theis Lange, Christian Ditlev Tuxen, Mette Rauhe Mouridsen, Trine Kiilerich Lauridsen, Jens Jakob Thune, Peter Godsk Jørgensen, Morten Lamberts, Nadia Paarup Dridi, Peter Bonfils, Morten Petersen, Nis Ottesen Stride, Anders Barasa, Jesper Jensen, Caroline Garred, Emil Fosbøl, Emil Wolsk, John McMurray, Mark Petrie, Morten Schou   +21 more
wiley   +1 more source

“Short Comunication” The Effect of Clinical Nursing Services Accreditation Training on the Knowledge and Attitude of Nurses

نشریه پرستاری ایران, 2017
Background & Aim: Accreditation refers to the systematic assessment of health care centers based on certain standards. The nursing accreditation system is a system that evaluates the capabilities of nurses. Given that nurses have ability to implement and
F Mir-Habibi, M Salsali, T Nasrabadi
doaj