Assessing the role of foliar habit on nutrient losses in a sub-Antarctic forest. [PDF]
EcologyPiper FI, Fajardo A.
europepmc +1 more source
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
Extreme precipitation reshapes nutrient flows and balance in North America's largest river basin. [PDF]
Sci AdvBian Z +6 more
europepmc +1 more source
Managing the Black Sea Anchovy Fishery with Nutrient Enrichment and a Biological Invader [PDF]
Many marine systems are subject to high nutrient loadings together with invasions by exotic species. Devising appropriate management responses is an increasing concern and one that has received relatively little attention from researchers.
Barbier, Edward B., Knowler, Duncan
core +1 more source
Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett +8 more
wiley +1 more source
Environmental context shapes sex-specific costs of reproduction in a dioecious plant. [PDF]
Ann BotGibson MT, Emery RJN, Dorken ME.
europepmc +1 more source
Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang +10 more
wiley +1 more source
Preferential Nitrogen and Phosphorus Reallocation to Apical Needles Drives Basal Needle Chlorosis in <i>Pinus sylvestris</i> L. Plantations in the Otindag Sandy Land. [PDF]
Biology (Basel)Zhang X, Jia C, Miao B, Wang Y, Liang C.
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao +6 more
wiley +1 more source